Skip to main content

Table 1 Population characteristics and univariate analysis on the association between population characteristics and 4 areas of treatment

From: Incidence and associated factors of cetuximab-induced hypersensitivity infusion reactions in 1392 cancer patients treated in four French areas: a possible association with Lyme disease?

Characteristics

Total (N = 1392)

High-risk areaa Limoges (N = 266)

Medium-risk areab

Nancy (N = 467)

Low-risk areac Reims (N = 407)

Very-low-risk aread

Amiens (N = 252)

P-value

 

Age (years), median (inter-quartile)

63.0 (56–70)

64.5 (57–72)

62.0 (55–68)

63.0 (56–71)

63.0 (58–70)

0.0064

 

Sex

       
 

Male, N (%)

1091 (78.4)

199 (74.8)

368 (78.8)

329 (80.8)

195 (77.4)

NS

 
 

Female, N (%)

301 (21.6)

67 (25.2)

99 (21.2)

78 (19.2)

57 (22.6)

NS

 

Primary cancer locations

       
 

HNSCC, N (%)

958 (68.8)

159 (59.8)

330 (70.7)

283 (69.5)

186 (73.8)

0,003

 
 

Colorectal, N (%)

347 (24.9)

99 (37.2)

114 (24.4)

79 (19.4)

55 (21.8)

< 10− 4

 
 

CSCC, N (%)

65 (4.7)

7 (2.6)

8 (1.7)

44 (10.8)

6 (2.4)

NS

 
 

Cervical, N (%)

2 (0.1)

0

0

1 (0.3)

1 (0.4)

NS

 
 

Other, N (%)

20 (1.4)

1 (0.4)

15 (3.2)

0

4 (1.6)

NS

 

Premedications

       
 

Corticosteroids alone, N (%)

19 (1.4)

1 (0.4)

1 (0.2)

15 (3.7)

2 (0.8)

NS

 
 

H1A alone, N (%)

11 (0.8)

0

4 (0.9)

7 (1.7)

0

NS

 
 

Corticosteroids + H1A, N (%)

1361 (97.8)

265 (99.6)

462 (98.9)

384 (94.6)

250 (99.2)

< 10− 4

 

Types of chemotherapy

       
 

Monotherapy, N (%)

49 (3.5)

11 (4.1)

5 (1.1)

32 (7.9)

1 (0.4)

NS

 
 

Polychemotherapy, N (%)

911 (65.5)

205 (77.1)

335 (71.7)

198 (48.6)

173 (68.6)

NS

 
 

Concomittant radiotherapy, N (%)

432 (31)

50 (18.8)

127 (27.2)

177 (43.5)

78 (31)

NS

 
  1. N, number of patients; HNSCC, head and neck squamous-cell carcinoma; CSCC, cutaneous squamous-cell carcinoma; H1A, histamine-1 receptor antagonist; NS, not significant. a, b, c, d defined according to estimated mean annual regional incidence rates of Lyme disease from Septfons A, et al. Eurosurveillance. 2019;24(11). doi:https://doi.org/10.2807/1560-7917.ES.2019.24.11.1800134 [41] : a > 150 / 100,000 inhabitants; b 50–100 / 100,000 inhabitants; c 20–50 / 100,000 inhabitants; d 5–20 / 100,000 inhabitants