Table 1 Descriptive analysis of MSS CRC cases diagnosed at CMJAH between (2011–2015). Categorized by site: LCC vs RCC and Ethnicity: Indigenous African (IA) vs Other Ethnic Group (OEG)

Frequency

369

154 (42)

108(29)

63(17)

44(12)

Demographical data

GENDER

369

154

108

P = 0.0111*

63

44

P = 0.6932

Male

209(57)

98(64)*

51(47)

34(54)

26(59)

Female

160(43)

56(36)

57(53)

29(46)

18(41)

AGE

365

152

107

P < 0.0001***

62

44

P = 0.0103*

Min–Max

15–92

20–90

28–92

15–79

25–86

Mean ± SD

57 ± 14

53 ± 15

62 ± 13

54 ± 13

60 ± 11

Median

59

54***

62***

55*

61*

P25-P75 (Interquartile Range)

47–67

41–65

55–72

47–64

54–68

95% CI

[55-58]

[51-56]

[60-65]

[51-57]

[57-65]

Categorical Age

365

152

107

P < 0.0001***

62

44

P < 0.0001***

 ≤ 50 years

107 (29)

62(41)***

15(14)

24(39)***

6(14)

 > 50 years

258(71)

90(59)

92(86)

38(61)

38(86)

Histological characteristics

TUMOUR SUBTYPE

360

152

104

P = 0.0257*

61

43

P = 0.2608

Invasive Adenocarcinoma

329(91)

138(91)

100(96)

54(89)

35(81)

Mucinous Adenocarcinoma

17(5)

4(3)

4(4)

3(5)

6(14)

Signet Ring Cell Adenocarcinoma

14(4)

10(6)

0(0)

4(6)

2(5)

TUMOUR SITE:

359

151

105

P = 0.0221*

61

42

P = 0.2431

Left

Right

Splenic Flexure

Hepatic Flexure

14(4)

5(3)

0(0)

6(10)

3(7)

Descending colon

Ascending Colon

58(16)

21(14)

11(10)

11(18)

15(36)

Sigmoid

Transverse Colon

83(23)

46(31)*

21(20)

10(16)

6(14)

Rectum

Caecum

204(57)

79(52)

73(70)

34(56)

18(43)

TUMOUR GRADE

348

148

95

P = 0.0930

61

44

P = 1.0000

Low Grade (LG)

316(91)

132(89)

91(96)

54(89)

39(89)

High Grade (HG)

32(9)

16(11)

4(4)

7(11)

5(11)

AJCC TNM STAGING

240

85

61

P = 0.0922

57

37

P = 0.4995

I-II

92(38)

31(38)

31(51)

20(36)

10(27)

III-IV

148(62)

54(62)

30(49)

37(64)

27(73)

TUMOUR INFILTRATING LYMPHOCYTES (TIL)

230

81

60

P = 0.8512

54

35

P = 0.6591

None

156(68)

58(72)

44(73)

34(63)

20(57)

Mild-moderate

74(32)

23(28)

16(27)

20(37)

15(43)

CROHN'S LIKE INFLAMMATORY RESPONSE

230

81

60

P = 0.4406

54

35

P = 0.3392

None

168(73)

62(77)

42(70)

41(76)

23(66)

Mild-moderate

62(27)

19(23)

18(30)

13(24)

12(34)

LYMPHATIC INVASION

285

115

76

P = 0.2921

56

38

P = 0.2896

Absent

203(71)

85(74)

62(82)

36(64)

20(53)

Present

82(29)

30(26)

14(18)

20(36)

18(47)

VENOUS INVASION

232

82

59

P = 0.3937

55

36

P = 1.0000

Absent

181(78)

68(83)

45(76)

41(75)

27(75)

Present

51(22)

14(17)

14(24)

14(25)

9(25)

PERINEURAL INVASION

241

91

60

P = 0.1110

54

36

P = 1.0000

Absent

187(78)

67(74)

51(85)

41(76)

28(78)

Present

54(22)

24(26)

9(15)

13(24)

8(22)

POLYPS

80

31

19

P = 0.5516

16

14

P = 0.7131

Tubular Adenoma (TA)

49(58)

21(68)

11(58)

10(63)

7(50)

Tubulovillous Adenoma (TVA)

31(37)

10(32)

8(42)

6(37)

7(50)

MSS/MSI-L PCR CONFIRMED CASES

233

94

85

P = 0.0157*

28

26

P = 0.3582

MSS

189(81)

72(77)

77(91)

19(70)

21(81)

MSI-L

44(19)

22(23)

8(9)

9(30)

5(19)

MSI PCR MARKERS (MSI-L)

42

22

8

P = 0.0138*

7

5

P = 0.2222

1 single unstable marker

BAT25/26

BAT25/26

BAT25

20(56)

11(50)*

5(62.5)

Vs

3((43)

1(20)

Vs

BAT26

15(22)

11(50)*

0(0)

NR21/24/27

3(43)

1(20)

NR21/24/27

NR21

4(12)

0(4)

2(25)

0(0)

2(40)

NR24

3(10)

0(0)

1(12.5)

1(14)

1(20)

NR27

0(0)

0(0)

0(0)

0(0)

0(0)