Table 2 Univariate and multivariate analysis of the Breast Cancer disease-free survival by Cox regression analysis
From: Tumour stroma ratio is a potential predictor for 5-year disease-free survival in breast cancer
Characteristics | Number of patients | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|---|
HR(95%CI) | P value | HR(95%CI) | P value | ||
Age | |||||
|  | 240 | 0.99(0.97–1.01) | 0.369 | 0.98(0.95–1.02) | 0.394 |
Histopathological Grade | |||||
 I | 40 | ref |  | ref |  |
 II | 141 | 3.21(1.15–8.98) | 0.026 | 1.69(0.59–4.87) | 0.327 |
 III | 59 | 15.28(5.48–42.59) | 0.000 | 5.92(1.98–17.74) | 0.001 |
Nodal status | |||||
 Negative | 109 | ref |  | ref |  |
 Positive | 131 | 5.04(2.97–8.54) | 0.000 | 3.78(2.17–6.60) | 0.000 |
ER status | |||||
 Negative | 134 | ref |  | ref |  |
 Positive | 106 | 0.56(0.38–0.83) | 0.004 | 0.95(0.63–1.43) | 0.796 |
HER-2 status | |||||
 Negative | 189 | ref |  | ref |  |
 Positive | 51 | 1.95(1.26–3.01) | 0.003 | 1.78(1.09–2.89) | 0.020 |
PR status | |||||
 Negative | 133 | ref |  | ref |  |
 Positive | 107 | 0.66(0.50–0.88) | 0.005 | 1.00(0.72–1.40) | 0.986 |
Menopausal status | |||||
 Premenopausal | 134 | ref |  | ref |  |
 Postmenopausal | 106 | 1.41(0.934–2.12) | 0.103 | 1.45(0.76–2.79) | 0.261 |
Tumor size (in cm) | |||||
 T1 (T ≤ 2) | 35 | ref |  | ref |  |
 T2 (2 < T ≤ 5) | 162 | 3.62(1.31–9.95) | 0.013 | 3.23(1.16–8.99) | 0.025 |
 T3 (T > 5) | 43 | 8.31(2.90–23.79) | 0.000 | 4.26(1.45–12.53) | 0.009 |
TSR | |||||
 Stroma-low | 153 | ref |  | ref |  |
 Stroma-high | 87 | 2.69(1.78–4.06) | 0.000 | 2.82(1.81–4.40) | 0.000 |