Fig. 2

Changes in CCR7 expression levels and the invasive ability of KYSE cells due to the regulation of let-7a expression. A Overexpression of let-7a decreased CCR7 expression levels in five out of six KYSE cell lines. (* p < 0.05 versus wild-type). B Downregulation of let-7a increased CCR7 expression levels in KYSE 590 cells (p < 0.001). (* p < 0.05 versus wild-type). C) Increase in invasion ability of KYSE 590 cells after downregulation of let-7a (p = 0.061)