PIK3CA mutations associated with a poor postoperative prognosis in patients with pulmonary pleomorphic carcinoma: a retrospective cohort study

Table 2 Cox proportional hazards analysis of OS according to the gene mutation status

	N	Death, N (%)	Unadjusted HR (95% CI), P	Adjusted HR^a (95% CI), P
TP53
VUSs/WT	29	7 (24)	Reference	Reference
Mut	26	8 (31)	1.3 (0.5–3.6), 0.63	0.9 (0.3–3.1), 0.95
PIK3CA
VUSs/WT	51	12 (24)	Reference	Reference
Mut	4	3 (75)	4.3 (1.2–15.7), 0.03	4.5 (1.1–18.8), 0.04
EGFR
VUSs/WT	50	13 (26)	Reference	Reference
Mut	5	2 (40)	1.2 (0.3–5.3), 0.82	0.6 (0.1–2.8), 0.47

HR Hazard ratio, Mut Pathogenic mutation, OS Overall survival, TP53 gene encoded tumor protein p53, VUSs Variants of unknown significance, WT Wild type, PIK3CA Gene encoded phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, EGFR Gene encoded epidermal growth factor receptor
^aAdjusted for pathological stage and age

ISSN: 1471-2407