B7-H4 is a potential diagnostic and prognostic biomarker in colorectal cancer and correlates with the epithelial-mesenchymal transition

Table 1 Correlation between B7-H4 mRNA expression and clinicopathological characteristics of CRC patients from the TCGA database

Characteristics	Total (N)	B7-H4 mRNA low expression	B7-H4 mRNA high expression	P-value
N	642	209	433
Age (yr)
≤ 60	197	56	141	0.137
> 60	445	153	292	0.137
Gender
Male	341	109	232	0.734
Female	301	100	201	0.734
Tumor location
Colon	478	152	326	0.486
Rectum	164	57	107	0.486
Depth of tumor invasion
T1/2	132	46	86	0.528
T3/4	510	163	347	0.528
Lymph node metastasis
N0	370	126	244	0.344
N1/2	272	83	189	0.344
Distant metastasis
No	542	178	364	0.310
Yes	91	25	66	0.310
Not available	9	6	3
TNM stage
I/II	354	120	234	0.267
III/IV	279	83	196	0.267
Not available	9	6	3
Neural invasion
Yes	60	27	33	0.018*
No	173	49	124	0.018*
Not available	409	133	276
Vascular invasion
Yes	135	41	94	0.411
No	424	145	279	0.411
Not available	83	23	60
Residual tumor
R0	466	158	338	0.076
R1/R2	42	19	23	0.076
Not available	134	32	72
Recurrence
Yes	125	34	91	0.155
No	517	175	342
Alive	515	170	345

ISSN: 1471-2407