Fig. 2

A schematic representation of CYP2D6 gene cluster and DNA sequence chromatograms of the investigated variants. A CYP2D6 gene and the two homologous CYP2D7 and CYP2D8 pseudogenes located on the long arm of chromosome 22 (22q13.2). B CYP2D6 gene containing nine exons. 100C>T is located on the first exon (yellow box), 1847G>A is located on the third intron (red box), and 2851C>T as well as 2989G>A are located on the sixth intron (blue box). C Chromatograms in the upper line represent homozygosity of the wild type allele, the second line represent the heterozygosity and the lower line represent homozygosity of the variant allele. D CYP2D6 inferred haplotypes according to the resultant sequencing chromatograms