Fig. 2

SMI#9 synergistically enhances paclitaxel (PTX) sensitivity in BRCA1 wild type and mutant TNBC cell lines. MDA-MB-468 (A-C) and HCC1937 (D-F) cells were treated with PTX alone at the indicated concentrations or along with 0.75 µM SMI#9 and proliferating cells measured by MTT assays. C, F Combination indices (CI) were calculated with the CompuSyn software where a CI > 1 indicates antagonism, CI < 1 indicates synergy, and CI = 1 indicates an additive effect. Results are expressed as mean ± S.E.M from three independent experiments. *P < 0.05, **P < 0.005, ****P < 0.00005