Table 1 Selected gene products regulated by metformin

p53 Signaling

MDM2

2.43

2.44E-05

SIAH-1

4.14

2.57E-02

GADD45a

5.41

2.45E-10

GADD45b

6.68

1.19E-03

GADD45g

4.88

9.80E-09

THBS1

4.87

3.59E-15

Prostate Cancer

PSA (KLK3)

−3.85

2.45E-104

KLK2

−3.55

7.70E-33

NKX3.1

−3.24

8.26E-102

CDKN1A (p21)

4.86

1.28E-10

CDKN1B (p27)

1.92

8.94E-03

CCND1

−4.66

1.87E-08

CREBBP

4.70

2.44E-10

PPAR Signaling

CPT2

−11.28

4.76E-06

UBC

2.83

3.51E-11

PPARG

3.91

1.16E-03

Other Cancer Related

MYC

−2.91

1.07E-11

PARP1

−6.08

4.75E-16

DUSP1

225.85

6.87E-102

JUN

22.22

1.34E-146

FAS

12.24

8.83E-06

HES1

5.79

7.44E-06

MALAT1

1.83

9.07E-12