Table 1 Association between clinicopathological characteristics with the expression of c-Jun and p-c-Jun in 99 patients with hypopharyngeal squamous cell carcinoma

Age (years)

0.7826

0.1051

 ≤ 60

21

34

43

12

 > 60

18

26

40

4

Smoking

0.3084

0.3451

 No

12

13

23

2

 Yes

27

47

60

14

Drinking

0.0754

0.6287

 No

14

18

26

6

 Yes

42

25

57

10

Tumor site

0.2371

0.6869

 Pyriform sinus

36

50

71

15

 Not pyriform sinus

3

10

12

1

cT stage

0.0401*

0.0627

 T1–2

23

24

36

11

 T3–4

15

37

47

5

cN stage

0.3917

0.4534

 N0

4

11

14

1

 N1–3

35

49

69

15

Clinical stage

> 0.9999

0.5889

 I + II

2

3

5

0

 III + IV

37

57

78

16

pT stage

0.2343

0.0615

 T1–2

19

22

31

10

 T3–4

20

38

52

6

pN stage

> 0.9999

0.2031

 N0

4

7

11

0

 N1–3

35

53

72

16

Pathological stage

0.7935

0.7545

 I + II + III

10

14

21

3

 IV

29

46

62

13

Tumor differentiation

0.0108†

> 0.9999

 Well+ well-moderately

0

9

8

1

 Moderately+ moderately-poorly

39

51

75

15

Surgical margin status

0.1742

0.2558

 ≥ 0.5 cm

16

33

39

10

 < 0.5 cm

23

27

44

6

Tumor size (cm)

0.0276*

0.7960

 ≤ 3.5

26

33

49

10

 > 3.5

9

31

34

6

Lymph nodal fusion

0.1974

0.2646

 No

26

47

63

10

 Yes

13

13

20

6

Number of lymph node metastases

0.0205†

< 0.0001†

 ≤ 1

36

44

68

12

 > 1

3

16

4

15

Metastatic lymph node size (cm)

0.1183

0.3868

 ≤ 3

22

43

56

9

 > 3

17

17

27

7

Cervical nodal necrosis

0.6438

0.0509

 No

22

31

48

5

 Yes

17

29

35

11

Lymphovascular invasion

> 0.9999

0.1577

 No

36

54

77

13

 Yes

3

6

6

3

Extracapsular spread

0.1522

0.1400

 No

27

49

66

10

 Yes

12

11

17

6

Fixation of hemilarynx

0.1764

0.0798

 No

21

24

34

11

 Yes

18

36

48

6

Thyroid gland invasion

0.6455

0.0344†

 No

38

56

80

14

 Yes

1

4

2

3

Laryngeal invasion

0.6306

0.7285

 No

15

26

35

6

 Yes

24

34

48

10

Ki-67 expression

0.0534

0.9513

 ≤ 30%

17

38

46

9

 > 30%

22

22

37

7

HPV infection status

0.2303

0.6611

 No

31

53

71

13

 Yes

8

7

12

3