Skip to main content

Table 1 Clinicopathological information, elasticity parameters, category of collagen fiber, and COL1A1 expression of 94 cases

From: Collagen fiber features and COL1A1: are they associated with elastic parameters in breast lesions, and can COL1A1 predict axillary lymph node metastasis?

Parameters

Benign (n = 30)

Malignant (n = 64)

LNM- (n = 39) LNM + (n = 25)

F/χ2

P value

Age (years)

44.230 ± 8.947

47.36 ± 8.725

48.24 ± 9.926

1.55

0. 22

Size (cm)

2.003 ± 0.615

2.121 ± 0.591

2.408 ± 0.778

2.74

0.07

Elastic parameters

 Emax (kPa)

44.450 ± 20.960

90.692 ± 48.697

131.696 ± 57.104

26.33

 < 0.001

 Emean (kPa)

33.687 ± 18.466

53.331 ± 23.278

91.280 ± 35.102

35.01

 < 0.001

 Emin (kPa)

20.320 ± 14.422

25.877 ± 19.415

27.068 ± 17.253

1.26

0.29

 Eratio

1.927 ± 0.516

3.454 ± 1.594

6.112 ± 2.338

46.79

 < 0.001

Expression of COL1A1

0.105 ± 0.323

0.140 ± 0.456

0.188 ± 0.332

31.72

 < 0.001

Category of Collagen fiber (n, %)

 0

25 (83)

10 (25.6)

3 (12)

35.016

 < 0.001

 1

5 (17)

20 (51.3)

5 (20)

  

 2

0

9 (23.1)

17 (68)

  

Estrogen receptor (n, %)

-

  

0.270

0.603

 Positive

-

29 (74.4)

20 (80)

  

 Negative

-

10 (25.6)

5 (20)

  

Progesterone receptor (n, %)

-

  

1.340

0.247

 Positive

-

26 (66.7)

20 (80)

  

 Negative

-

13 (33.3)

5 (20)

  

HER2 status (n, %)

-

  

3.770

0.276

 0, 1 + 

-

13 (33.3)

7 (28)

  

 2 + 

-

18 (46.2)

14 (56)

  

 3 + 

-

8 (20.5)

4 (16)

  

Ki‑67 index (%) (n, %)

-

  

6.140

0.013

  < 20

-

18 (46.2)

4 (16)

  

  ≥ 20

-

21 (53.8)

21 (84)

  
  1. Emax, maximum elasticity; Emean, mean elasticity; Emin, minimum elasticity; Eratio, elasticity ratio of the lesions to the peripheral tissue, COL1A1 Collagen type I alpha 1, AOD Average optical density