Table 4 Correlation analysis between NR1H4 and markers of immune cells in ccRCC by TIMER
From: Clinical significance and oncogenic function of NR1H4 in clear cell renal cell carcinoma
Description | Gene markers | ccRCC | ||||
|---|---|---|---|---|---|---|
None | Purity | |||||
Correlation | p value | Correlation | p value | |||
CD8 + T cell | CD8A | 0.026 | 0.554 | -0.030 | 0.514 | |
CD8B | -0.023 | 0.594 | -0.091 | 0.051 | ||
T cell (general) | CD3D | -0.055 | 0.208 | -0.112 | 0.016 | |
CD3E | -0.035 | 0.425 | -0.088 | 0.060 | ||
CD2 | 0.021 | 0.632 | -0.031 | 0.513 | ||
B cell | CD19 | -0.053 | 0.220 | -0.082 | 0.077 | |
CD79A | -0.061 | 0.163 | -0.116 | 0.013 | ||
Monocyte | CD86 | 0.172 | *** | 0.152 | * | |
CD115 (CSF1R) | 0.145 | ** | 0.124 | * | ||
TAM | CCL2 | 0.162 | ** | 0.165 | ** | |
CD68 | 0.385 | *** | 0.342 | *** | ||
IL10 | 0.169 | *** | 0.162 | ** | ||
M1 macrophage | INOS (NOS2) | 0.022 | 0.616 | -0.015 | 0.747 | |
IRF5 | 0.230 | *** | 0.194 | *** | ||
COX2(PTGS2) | 0.092 | 0.034 | 0.128 | * | ||
M2 macrophage | CD163 | 0.250 | *** | 0.242 | *** | |
VSIG4 | 0.189 | *** | 0.167 | ** | ||
MS4A4A | 0.186 | *** | 0.181 | *** | ||
Neutrophils | CD66b (CEACAM8) | 0.040 | 0.362 | 0.041 | 0.379 | |
CD11b (ITGAM) | 0.189 | *** | 0.164 | ** | ||
CCR7 | 0.050 | 0.249 | 0.022 | 0.637 | ||
Natural killer cell | KIR2DL1 | 0.027 | 0.530 | 0.024 | 0.605 | |
KIR2DL3 | -0.009 | 0.840 | -0.024 | 0.602 | ||
KIR2DL4 | 0.003 | 0.948 | -0.002 | 0.967 | ||
KIR3DL1 | 0.002 | 0.971 | -0.017 | 0.719 | ||
KIR3DL2 | -0.030 | 0.494 | -0.046 | 0.328 | ||
KIR3DL3 | 0.002 | 0.970 | 0.008 | 0.858 | ||
KIR2DS4 | -0.004 | 0.921 | -0.006 | 0.890 | ||
Dendritic cell | HLA-DPB1 | 0.092 | 0.034 | 0.039 | 0.408 | |
HLA-DQB1 | 0.064 | 0.140 | -0.005 | 0.915 | ||
HLA-DRA | 0.179 | *** | 0.137 | * | ||
HLA-DPA1 | 0.177 | *** | 0.146 | * | ||
BDCA-1 (CD1C) | 0.068 | 0.116 | 0.039 | 0.398 | ||
BDCA-4 (NRP1) | 0.302 | *** | 0.296 | *** | ||
CD11c (ITGAX) | 0.045 | 0.300 | 0.042 | 0.367 | ||
Th1 | T-bet (TBX21) | -0.070 | 0.107 | -0.103 | 0.027 | |
STAT4 | 0.102 | 0.019 | 0.077 | 0.100 | ||
STAT1 | 0.257 | *** | 0.227 | *** | ||
IFN-γ (IFNG) | 0.008 | 0.849 | -0.046 | 0.329 | ||
TNF-α (TNF) | -0.008 | 0.849 | -0.019 | 0.679 | ||
Th2 | GATA3 | -0.302 | *** | -0.318 | *** | |
STAT6 | 0.380 | *** | 0.370 | *** | ||
STAT5A | 0.085 | 0.051 | 0.065 | 0.165 | ||
IL13 | 0.033 | 0.454 | 0.023 | 0.628 | ||
T fh | BCL6 | 0.213 | *** | 0.206 | *** | |
IL21 | -0.002 | 0.967 | -0.005 | 0.918 | ||
Th17 | STAT3 | 0.316 | *** | 0.302 | *** | |
IL17A | 0.040 | 0.356 | 0.067 | 0.152 | ||
Treg | FOXP3 | 0.028 | 0.518 | 0.011 | 0.814 | |
CCR8 | 0.178 | *** | 0.158 | ** | ||
STAT5B | 0.276 | *** | 0.256 | *** | ||
TGF-β (TGFB1) | 0.083 | 0.054 | 0.069 | 0.140 | ||
T cell exhaustion | PD-1 (PDCD1) | -0.026 | 0.548 | -0.079 | 0.091 | |
CTLA4 | 0.055 | 0.205 | 0.020 | 0.671 | ||
TIM-3 (HAVCR2) | 0.210 | *** | 0.167 | ** | ||
GZMB | -0.178 | *** | -0.227 | *** | ||
LAG3 | -0.046 | 0.291 | -0.093 | 0.046 | ||
PDL1 (CD274) | 0.233 | *** | 0.245 | *** | ||