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Table 4 Correlation analysis between NR1H4 and markers of immune cells in ccRCC by TIMER

From: Clinical significance and oncogenic function of NR1H4 in clear cell renal cell carcinoma

Description Gene markers ccRCC  
None   Purity
   Correlation p value   Correlation p value
CD8 + T cell CD8A 0.026 0.554   -0.030 0.514
  CD8B -0.023 0.594   -0.091 0.051
T cell (general) CD3D -0.055 0.208   -0.112 0.016
  CD3E -0.035 0.425   -0.088 0.060
  CD2 0.021 0.632   -0.031 0.513
B cell CD19 -0.053 0.220   -0.082 0.077
  CD79A -0.061 0.163   -0.116 0.013
Monocyte CD86 0.172 ***   0.152 *
  CD115 (CSF1R) 0.145 **   0.124 *
TAM CCL2 0.162 **   0.165 **
  CD68 0.385 ***   0.342 ***
  IL10 0.169 ***   0.162 **
M1 macrophage INOS (NOS2) 0.022 0.616   -0.015 0.747
  IRF5 0.230 ***   0.194 ***
  COX2(PTGS2) 0.092 0.034   0.128 *
M2 macrophage CD163 0.250 ***   0.242 ***
  VSIG4 0.189 ***   0.167 **
  MS4A4A 0.186 ***   0.181 ***
Neutrophils CD66b (CEACAM8) 0.040 0.362   0.041 0.379
  CD11b (ITGAM) 0.189 ***   0.164 **
  CCR7 0.050 0.249   0.022 0.637
Natural killer cell KIR2DL1 0.027 0.530   0.024 0.605
  KIR2DL3 -0.009 0.840   -0.024 0.602
  KIR2DL4 0.003 0.948   -0.002 0.967
  KIR3DL1 0.002 0.971   -0.017 0.719
  KIR3DL2 -0.030 0.494   -0.046 0.328
  KIR3DL3 0.002 0.970   0.008 0.858
  KIR2DS4 -0.004 0.921   -0.006 0.890
Dendritic cell HLA-DPB1 0.092 0.034   0.039 0.408
  HLA-DQB1 0.064 0.140   -0.005 0.915
  HLA-DRA 0.179 ***   0.137 *
  HLA-DPA1 0.177 ***   0.146 *
  BDCA-1 (CD1C) 0.068 0.116   0.039 0.398
  BDCA-4 (NRP1) 0.302 ***   0.296 ***
  CD11c (ITGAX) 0.045 0.300   0.042 0.367
Th1 T-bet (TBX21) -0.070 0.107   -0.103 0.027
  STAT4 0.102 0.019   0.077 0.100
  STAT1 0.257 ***   0.227 ***
  IFN-γ (IFNG) 0.008 0.849   -0.046 0.329
  TNF-α (TNF) -0.008 0.849   -0.019 0.679
Th2 GATA3 -0.302 ***   -0.318 ***
  STAT6 0.380 ***   0.370 ***
  STAT5A 0.085 0.051   0.065 0.165
  IL13 0.033 0.454   0.023 0.628
T fh BCL6 0.213 ***   0.206 ***
  IL21 -0.002 0.967   -0.005 0.918
Th17 STAT3 0.316 ***   0.302 ***
  IL17A 0.040 0.356   0.067 0.152
Treg FOXP3 0.028 0.518   0.011 0.814
  CCR8 0.178 ***   0.158 **
  STAT5B 0.276 ***   0.256 ***
  TGF-β (TGFB1) 0.083 0.054   0.069 0.140
T cell exhaustion PD-1 (PDCD1) -0.026 0.548   -0.079 0.091
  CTLA4 0.055 0.205   0.020 0.671
  TIM-3 (HAVCR2) 0.210 ***   0.167 **
  GZMB -0.178 ***   -0.227 ***
  LAG3 -0.046 0.291   -0.093 0.046
  PDL1 (CD274) 0.233 ***   0.245 ***
  1. TAM Tumor-associated macrophage, Th T helper cell, Tfh Follicular helper T cell, Treg Regulatory T cell, None, correlation without adjustment. Purity, correlation adjusted by purity
  2. * p < 0.01
  3. ** p < 0.001
  4. *** p < 0.0001