Fig. 1

Effect of AZD0156 and SN38 on proliferation in CRC cell lines. Percent confluence relative to vehicle at 120 h as assessed by Incucyte ZOOM™. AZD0156 at a dose of 100 nM alone and in combination with SN38 at a dose of 10 nM. Experiments performed with 3 replicates. *** = p ≤ 0.001 and **** = p ≤ 0.0001 when comparing AZD0156 alone to combination with SN38