Skip to main content

Table 3 Univariable and multivariable analyses of recurrence-free survival of patients with EGFR-Wt lung cancer

From: Prognostic factors for relapse-free survival in stage IB-IIIA primary lung adenocarcinoma by epidermal growth factor receptor mutation status

Recurrent-fee survival
Variable
Univariable analysis Multivariable analysis
HR 95% CI p value HR 95% CI p value
Age (≥65) 1.28 0.88–1.87 0.189    
Gender (Male) 1.66 1.13–2.47 0.013 1.71 0.97–3.00 0.062
Smoking history (+) 1.46 0.93–2.28 0.097 0.97 0.51–1.83 0.915
Side (left) 0.81 0.58–1.14 0.228    
CEA (> 10 ng/ml) 1.33 0.88–2.00 0.172    
CT tumor size (> 4.0 cm) 1.46 1.05–2.03 0.025 2.07 0.87–4.94 0.102
Consolidation size (> 4.0 cm) 1.47 1.05–2.05 0.025 0.84 0.34–2.07 0.707
GGO (−) 0.90 0.58–1.42 0.665    
PET maxSUV (≥6.0) 1.98 1.38–2.83 < 0.001 1.53 1.02–2.31 0.042
Surgical procedure (segmentectomy) 1.19 0.64–2.21 0.575    
Invasive lepidic adenocarcinoma 0.49 0.22–1.12 0.093 0.71 0.31–1.67 0.438
Invasive acinar adenocarcinoma 1.12 0.76–1.63 0.576    
Invasive papillary adenocarcinoma 1.24 0.86–1.80 0.244    
Invasive mucinous adenocarcinoma 0.58 0.32–1.05 0.072 0.74 0.36–1.49 0.393
Invasive solid adenocarcinoma 1.01 0.70–1.45 0.963    
Invasive micropapillary adenocarcinoma 1.29 0.32–5.21 0.720    
High-grade adenocarcinoma 1.17 0.83–1.64 0.378    
Lymphatic vessel invasion (+) 1.84 1.30–2.61 0.001 1.54 1.03–2.30 0.036
Blood vessel invasion (+) 1.55 1.10–2.17 0.011 1.18 0.79–1.77 0.424
Pleural invasion (+) 1.09 0.78–1.51 0.625    
Nodal metastasis (+) 2.90 1.94–4.34 < 0.001 1.79 1.23–2.60 0.002
Lepidic component (+) 1.30 0.94–1.80 0.118    
Solid component (+) 1.49 1.03–2.16 0.035 1.00 0.63–1.56 0.987
Micropapillary component (+) 1.35 0.97–1.87 0.078 1.21 0.85–1.73 0.298
Adjuvant chemotherapy (+) 0.73 0.51–1.04 0.081 0.60 0.42–0.88 0.008
  1. CT Computed tomography, GGO Ground glass opacity, PET Positron emission tomography, SUV Standardized uptake value, EGFR Epidermal growth factor receptor, HR Hazards ratio, CI Confidence interval