Variable | Total (n = 5048) | Preoperative CA19-9 group | P value | |
---|---|---|---|---|
Normal CA19-9 (n = 4310) | Elevated CA19-9 (n = 738) | |||
Hospital, n (%) |  |  |  |  < 0.001 |
 YNCH | 2170 (43.0) | 1843 (42.8) | 327 (44.3) |  |
 KYU1 | 1111 (22.0) | 986 (22.9) | 125 (16.9) |  |
 PUCH | 604 (12.0) | 541 (12.6) | 63 (8.5) |  |
 SYSU6 | 683 (13.5) | 545 (12.6) | 138 (18.7) |  |
 CQU1 | 480 (9.5) | 395 (9.2) | 85 (11.5) |  |
Male, n (%) | 3029 (60.0) | 2629 (61.0) | 400 (54.2) | 0.001 |
Agea | 61.0 [51.0, 68.0] | 61.0 [51.0, 68.0] | 62.0 [51.0, 69.0] | 0.114 |
Preoperative CEA, ng/ml a | 3.8 [2.1, 9.4] | 3.5 [2.0, 7.3] | 10.6 [4.3, 28.1] |  < 0.001 |
Preoperative CEA group, n (%) |  |  |  |  < 0.001 |
 ≥ 5 ng/ml | 2043 (40.5) | 1519 (35.2) | 524 (71.0) |  |
 < 5 ng/ml | 3005 (59.5) | 2791 (64.8) | 214 (29.0) |  |
Preoperative CA19-9, U/ml a | 11.9 [7.3, 23.4] | 11.4 [6.4, 16.8] | 69.7 [48.3, 143.5] |  < 0.001 |
Primary site, n (%) |  |  |  |  < 0.001 |
 Colon | 2659 (52.7) | 2216 (51.4) | 443 (60.0) |  |
 Rectum | 2389 (47.3) | 2094 (48.6) | 295 (40.0) |  |
Surgical approach, n (%) | Â | Â | Â | 0.079 |
 Laparoscopic resection | 3010 (59.6) | 2596 (60.2) | 414 (56.1) |  |
 Open resection | 2035 (40.3) | 1711 (39.7) | 324 (43.9) |  |
 Unknown | 3 (0.1) | 3 (0.1) | 0 (0.0) |  |
AJCC 8th ed. Stage, n (%) | Â | Â | Â | Â |
 II | 2724 (54.0) | 2403 (55.8) | 321 (43.5) |  < 0.001 |
 III | 2324 (46.0) | 1907 (44.2) | 417 (56.5) |  |
Lymph node yield, n (%) | Â | Â | Â | 0.216 |
 ≥ 12 | 3883 (76.9) | 3305 (76.7) | 578 (78.3) |  |
 < 12 | 1163 (23.0) | 1004 (23.3) | 159 (21.5) |  |
 Unknown | 2 (0.0) | 1 (0.0) | 1 (0.1) |  |
Tumor differentiation, n (%) | Â | Â | Â | 0.002 |
 Well-moderate | 3533 (70.0) | 3052 (70.8) | 481 (65.2) |  |
 Poor-undifferentiated | 1040 (20.6) | 853 (19.8) | 187 (25.3) |  |
 Unknown | 475 (9.4) | 405 (9.4) | 70 (9.5) |  |
Lymphovascular / Perineural invasion, n (%) | Â | Â | Â | 0.020 |
 Yes | 1168 (23.1) | 969 (22.5) | 199 (27.0) |  |
 No | 3759 (74.5) | 3240 (75.2) | 519 (70.3) |  |
 Unknown | 121 (2.4) | 101 (2.3) | 20 (2.7) |  |
MSI, n (%) | Â | Â | Â | 0.272 |
 Yes | 886 (17.6) | 751 (17.4) | 135 (18.3) |  |
 No | 2354 (46.6) | 2030 (47.1) | 324 (43.9) |  |
 Unknown | 1808 (35.8) | 1529 (35.5) | 279 (37.8) |  |
Adjuvant chemotherapy, n (%) | Â | Â | Â | 0.261 |
 Yes | 3576 (70.8) | 3035 (70.4) | 541 (73.3) |  |
 No | 1471 (29.1) | 1274 (29.6) | 197 (26.7) |  |
 Unknown | 1 (0.0) | 1 (0.0) | 0 (0.0) |  |
Mucinous (colloid) type, n (%) |  |  |  |  < 0.001 |
 Yes | 395 (7.8) | 303 (7.0) | 92 (12.5) |  |
 No | 4648 (92.1) | 4002 (92.9) | 646 (87.5) |  |
 Unknown | 475 (9.4) | 405 (9.4) | 70 (9.5) |  |