Table 2 Differential analysis in IAC and MIA according to the pathological components of the area adjacent pleura and CT manifestation
Variable | IAC | MIA | ||||||
|---|---|---|---|---|---|---|---|---|
Alveoli/Lepidic (n = 11) | Acinar/Papillary (n = 20) | Total (n = 31) | P δvalue | Alveoli/Lepidic (n = 43) | Acinar/Papillary (n = 7) | Total (n = 50) | Pεvalue | |
Age Median (25th to 75th percentile) years | 55.00(48.00, 63.00) | 61.00(51.75, 64.00 | 60.00(49.00,64.00) | 0.353 | 60.00(46.00, 66.00) | 54.00(51.00,63.00) | 59.50(50.50,64.25) | 0.541 |
Sex/Male, No. (%) | 3(27.27%) | 4(20.00%) | 7(22.58%) | 0.676 | 14(32.56%) | 3(42.86%) | 17(34.00%) | 0.677 |
Smoking history, No. (%) | 2(18.18%) | 2(10.00%) | 4(12.90%) | 0.601 | 2(4.65%) | 0(0.00%) | 2(4.00%) | 0.737 |
Subpleural histologic patterns, No. (%) | – | – | ||||||
Alveoli/lepidic | 11(100.00%) | – | 11(35.48%) | 43(100.00%) | – | 43(86.00%) | ||
acinar/papillary | – | 20(100.00%) | 20(64.52%) | – | 7(100.00%) | 7(14.00%) | ||
Ki-67, No. (%) | 1.000 | 1.000 | ||||||
< 10% | 9(81.82%) | 13(76.47%) | 22(78.57%) | 39(97.50%) | 7(100.00%) | 46(97.87%) | ||
≥ 10% | 2(18.18%) | 4(23.53%) | 6(21.43%) | 1(2.50%) | 0(0.00%) | 1(2.13%) | ||
Absence | 0 | 3 | 3 | 3 | 0 | 3 | ||
Distance(mm), median (25th – 75th percentile) | 1.00(0.50, 3.00) | 0.00(0.00, 0.00) | 0.00(0.00, 1.00) | < 0.001 | 1.50(1.00, 2.00) | 0.00(0.00, 0.00) | 1.00(0.50, 2.00) | < 0.001 |
Depth(mm) median (25th – 75th percentile) | 6.50(6.00, 9.00) | 7.00(5.00, 12.75) | 7.00(5.00, 10.00) | 0.573 | 1.50(0.50, 2.00) | 2.50(2.00, 7.00) | 1.50(0.50, 2.63) | 0.044 |
Tumor location, No. (%) | 0.136 | 0.672 | ||||||
Right upper lobe | 2(18.18%) | 11(55.00%) | 13(41.94%) | 14(32.56%) | 4(57.14%) | 18(36.00%) | ||
Right middle lobe | 0(0.00%) | 1(5.00%) | 1(3.23%) | 5(11.63%) | 1(14.29%) | 6(12.00%) | ||
Right lower lobe | 5(45.45%) | 4(20.00%) | 9(29.03%) | 7(16.28%) | 1(14.29%) | 8(16.00%) | ||
Left upper lobe | 4(36.36%) | 3(15.00%) | 7(22.58%) | 10(23.26%) | 0(0.00%) | 10(20.00%) | ||
Left lower lobe | 0(0.00%) | 1(5.00%) | 1(3.23%) | 7(16.28%) | 1(14.29%) | 8(16.00%) | ||
Shape, No. (%) | 1.000 | 1.000 | ||||||
Irregular | 4(36.36%) | 8(40.00%) | 12(38.71%) | 16(37.21%) | 2(28.57%) | 18(36.00%) | ||
Round and oval | 7(63.64%) | 12(60.00%) | 19(61.29%) | 27(62.79%) | 5(71.43%) | 32(64.00%) | ||
Lobulation, No. (%) | 0.716 | 0.234 | ||||||
Absent | 5(45.45%) | 11(55.00%) | 16(51.61%) | 14(32.56%) | 4(57.14%) | 18(36.00%) | ||
Presence | 6(54.55%) | 9(45.00%) | 15(48.39%) | 29(67.44%) | 3(42.86%) | 32(64.00%) | ||
vacoule, No. (%) | 1.000 | 1.000 | ||||||
Absent | 9(81.82%) | 15(75.00%) | 24(77.42%) | 31(72.09%) | 5(71.43%) | 36(72.00%) | ||
Presence | 2(18.18%) | 5(25.00%) | 7(22.58%) | 12(27.91%) | 2(28.57%) | 14(28.00%) | ||
AirBronchogram, No. (%) | 0.115 | 1.000 | ||||||
Absent | 8(72.73%) | 19(95.00%) | 27(87.10%) | 37(86.05%) | 6(85.71%) | 43(86.00%) | ||
Presence | 3(27.27%) | 1(5.00%) | 4(12.90%) | 6(13.95%) | 1(14.29%) | 7(14.00%) | ||
Pleural deformation, No. (%) | 0.033 | 0.359 | ||||||
Type a | 1(9.09%) | 3(15.00%) | 4(12.90%) | 10(23.26%) | 4(57.14%) | 14(28.00%) | ||
Type b | 4(36.36%) | 3(15.00%) | 7(22.58%) | 3(6.98%) | 0(0.00%) | 3(6.00%) | ||
Type c | 5(45.45%) | 3(15.00%) | 8(25.81%) | 8(18.60%) | 0(0.00%) | 8(16.00%) | ||
Type d | 1(9.09%) | 11(55.00%) | 12(38.71%) | 16(37.21%) | 3(42.86%) | 19(38.00%) | ||
Type e | 0(0.00%) | 0(0.00%) | 0(0.00%) | 6(13.95%) | 0(0.00%) | 6(12.00%) | ||
CTv (HU) | -577.67(-608.57, -540.99) | -572.89(-634.41, -515.82 | -575.57(-632.47, -518.47) | 0.919 | -654.24(-685.21, -606.12) | -632.84(-731.91, -599.28) | -647.94(-690.37, -605.85) | 0.978 |
MD (mm) | 14.60(13.10, 20.90) | 17.50(13.78, 24.88) | 16.80(13.20,23.90) | 0.495 | 13.30(10.40, 17.90) | 18.40(17.70,21.20) | 14.10(10.75,18.43) | 0.007 |
MVD (mm) | 11.20(8.46,15.40) | 14.95(11.25, 17.60) | 12.80(10.60,17.30) | 0.193 | 10.10(7.96, 13.10) | 15.00(10.90,17.30) | 10.45(7.98, 14.18) | 0.065 |