Table 6 Association between p53 immunohistochemical expression pattern and lymph node stage and TNM stage
From: Clinical significance of p53 protein expression and TP53 variation status in colorectal cancer
Characteristics | p53 IHC (DO-7) | p | p53 IHC (DO-7) | p | Total | p53 IHC (Bp53–11) | p | p53 IHC (Bp53–11) | p | p53 IHC (SP5) | p | p53 IHC (SP5) | p | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Wild type pattern (1 ~ 79%) | Missense pattern (≥80%) | Wild type pattern (1 ~ 79%) | Nonsense/frameshift pattern (0%) | Wild type pattern (1 ~ 49%) | Missense pattern (≥50%) | Wild type pattern (1 ~ 49%) | Nonsense/frameshift pattern (0%) | Wild type pattern (2 ~ 69%) | Missense pattern (≥70%) | Wild type pattern (2 ~ 69%) | Nonsense/frameshift pattern (≤1%) | ||||||||
N stage | |||||||||||||||||||
 N0 | 37 (42%) | 51 (58%) |  | 37 (66.1%) | 19 (33.9%) |  | 90 | 34 (37.8%) | 56 (62.2%) |  | 34 (66.7%) | 17 (33.3%) |  | 38 (43.7%) | 49 (56.3%) |  | 38 (65.5%) | 20 (34.5%) |  |
 N1–3 | 16 (21.1%) | 60 (78.9%) | 0.004 | 16 (43.2%) | 21 (56.8%) | 0.03 | 75 | 15 (20%) | 60 (80%) | 0.013 | 15 (40.5%) | 22 (59.5%) | 0.015 | 16 (22.2%) | 56 (77.8%) | 0.004 | 16 (39%) | 25 (61%) | 0.009 |
TNM stage | |||||||||||||||||||
 Stage I, II | 37 (41.1%) | 53 (58.9%) |  | 37 (64.9%) | 20 (35.1%) |  | 92 | 35 (38%) | 57 (62%) |  | 35 (66%) | 18 (34%) |  | 37 (42%) | 51 (58%) |  | 37 (62.7%) | 22 (37.3%) |  |
 Stage III, IV | 16 (21.6%) | 58 (78.4%) | 0.008 | 16 (44.4%) | 20 (55.6%) | 0.052 | 73 | 14 (19.2%) | 59 (80.8%) | 0.008 | 14 (40%) | 21 (60%) | 0.016 | 17 (23.9%) | 54 (76.1%) | 0.017 | 17 (42.5%) | 23 (57.5%) | 0.047 |