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Table 2 Correlation between ABUS features and ALNM in EBC lesions and correlation between ABUS* features and cancer staging

From: Prediction model of axillary lymph node status using automated breast ultrasound (ABUS) and ki-67 status in early-stage breast cancer

ABUS features

 

ALN status

Cancer staging

Total

(n = 469)

NALNM

(n = 291)

ALNM

(n = 178)

P

Stage I

(n = 165)

Stage II

(n = 304)

P

Distance to nipple

3.099 ± 1.984

3.155 ± 2.004

3.007 ± 1.953

0.4354

3.257 ± 1.918

3.013 ± 2.017

0.204

Distance to skin

0.670 ± 0.514

0.697 ± 0.543

0.626 ± 0.461

0.145

0.747 ± 0.591

0.628 ± 0.462

0.017

MD

2.276 ± 0.909

2.086 ± 0.893

2.587 ± 0.852

 < 0.001

1.474 ± 0.377

2.712 ± 0.809

 < 0.001

Margin

   

0.174

  

0.016

  Circumscribe

51

36(70.6)

15(29.4)

 

26(51.0)

25(49.0)

 

  Spiculated

240

155(64.6)

85(35.4)

 

85(35.4)

155(64.6)

 

  Angular

78

45(57.7)

33(42.3)

 

29(37.2)

49(62.8)

 

  Indistinct

100

55(55.0)

45(45.0)

 

25(25.0)

75(75.0)

 

Shape

   

0.002

  

0.036

  Regular

28

25(89.3)

3(10.7)

 

15(53.6)

13(46.4)

 

  Irregular

441

266(60.3)

175(39.7)

 

150(34.0)

291(66.0)

 

Echo pattern

   

0.011

  

0.018

  Hypoechoic

434

261(60.1)

173(39.9)

 

146(33.6)

288(66.4)

 

  Heterogeneous/complex cystic and solid

22

19(86.4)

3(13.6)

 

10(45.5)

12(54.5)

 

  Hyperechoic

13

11(84.6)

2(15.4)

 

9(69.2)

4(30.8)

 

Calcifications

   

0.028

  

0.138

  No

213

146(68.5)

67(31.5)

 

85(39.9)

128(60.1)

 

  Micro

248

140(56.5)

108(43.5)

 

77(31.0)

171(69.0)

 

  Macro

8

5(62.5)

3(27.5)

 

3(37.5)

5(62.5)

 

Orientation

   

0.840

  

0.046

  Parallel

431

268(62.2)

163(37.8)

 

146(33.9)

285(66.1)

 

  Nonparallel

38

23(60.5)

15(39.5)

 

19(50.0)

19(50.0)

 

Posterior features

   

 < 0.001

  

 < 0.001

  No posterior features

313

221(70.6)

92(29.4)

 

135(43.1)

178(56.9)

 

  Shadowing

77

28(36.4)

49(63.6)

 

13(16.9)

64(83.1)

 

  Enhancement

74

39(52.7)

35(47.3)

 

17(23.0)

57(77.0)

 

  Combined pattern

5

3(60.0)

2(40.0)

 

0(0)

5(100.0)

 

Hyperechoic halo

   

 < 0.001

  

0.005

  Negative

332

225(67.8)

107(32.2)

 

130(39.2)

202(60.8)

 

  Positive

137

66(48.2)

71(51.8)

 

35(25.5)

102(74.5)

 

Retraction phenomenon

   

0.208

  

0.792

  Negative

309

198(64.1)

111(35.9)

 

110(35.6)

199(64.4)

 

  Positive

160

93(58.1)

67(41.9)

 

55(34.4)

105(65.6)

 
  1. *ABUS Automated breast ultrasound, EBC Early-stage breast cancer, ALN Axillary lymph node, ALNM Axillary lymph node metastasis, NALNM No axillary lymph node metastasis, MD Maximum diameter