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Table 2 Proportion of patients reporting NIDL and overall combined FLIE score relative to experiencing complete response

From: Evaluating the impact of chemotherapy-induced nausea and vomiting on daily functioning in patients receiving dexamethasone-sparing antiemetic regimens with NEPA (netupitant/palonosetron) in the cisplatin setting: results from a randomized phase 3 study

Treatment group

CR

 

Patients reporting NIDL

FLIE overall combined score

Acute

Delayed

No. of patients

N

%

Mean (SD)

Median (range)

NEPA+DEX1

Yes

Yes

52

38

73.1

113.1 (16.6)

118.2 (28.7–126)

Yes

No

13

2

15.4

85.6 (26.8)

89.6 (23.6–120.5)

No

Yes

0

–

–

–

–

No

No

5

0

0

79.1 (30.5)

93.5 (31–102.2)

NEPA+DEX3

Yes

Yes

54

41

75.9

112.6 (17.8)

118.4 (31.1–126)

Yes

No

10

3

30

88.6 (23.1)

89.9 (46.9–115.7)

No

Yes

0

–

–

–

–

No

No

7

0

0

98.7 (10.9)

102.6 (74.8–105.9)

NEPA+DEX4

Yes

Yes

54

43

79.6

117 (8.4)

119.2 (99–126)

Yes

No

10

3

30

91.6 (29)

95.6 (27–124.2)

No

Yes

0

–

–

–

–

No

No

7

2

28.6

106.2 (16.9)

114.2 (80.1–121.1)

  1. Acute refers to 0–24 h after chemotherapy and delayed refers to 25–120 h after chemotherapy. NIDL is based on FLIE overall combined score. The FLIE questionnaire was completed on day 6 post-chemotherapy.
  2. Abbreviations: SD standard deviation, NIDL no impact on daily life, FLIE Functional Living Index-Emesis, CR complete response (no emetic episode and no use of rescue medication), NEPA a fixed combination of netupitant and palonosetron, DEX1 dexamethasone day 1, DEX3 dexamethasone day 1 to 3, DEX4 dexamethasone day 1 to 4