Table 1 The association of clinicopathological parameters with expression of CMTM4 and PD-L1 in HCC cohort

Age (years)^a

0.085

0.880

  < 60

68

36

32

63

14

49

  ≥ 60

22

7

15

21

5

16

Gender

0.881

0.310

 Male

80

38

42

74

18

56

 Female

10

5

5

10

1

9

HBV

0.259

0.473

 Positive

70

36

34

66

14

52

 Negative

19

7

12

17

5

12

AFP (ng/mL)

0.045

0.456

  < 400

57

23

34

54

11

43

  ≥ 400

32

20

12

29

8

21

Cirrhosis

0.401

0.578

 Yes

80

40

40

74

11

43

 No

9

3

6

9

8

21

Cirrhosis number

0.196

0.477

  < 3

56

30

26

51

13

38

  ≥ 3

33

13

20

32

6

26

Tumor number

0.261

0.250

 Single

79

36

43

73

18

55

 Multiple

11

4

7

11

1

10

Tumor size^b

0.329

0.898

  < 5 cm

56

29

27

52

12

40

  ≥ 5 cm

34

14

20

32

7

25

Differentiation

0.202

0.112

 Well

44

18

26

40

6

34

 Moderate-poor

46

25

21

44

13

31

TNM stage

0.334

0.198

 I

63

28

35

61

16

45

 II-IV

27

15

12

23

3

20

Tumor capsule

0.330

0.040

 Complete

42

18

24

38

15

30

 Incomplete

47

25

22

45

4

34

TB (μmol/L)

0.679

0.027

  < 14.053

56

28

28

52

16

36

  ≥ 14.053

33

15

18

31

3

28

ALT (U/L)

0.996

0.436

  < 48.360

60

29

31

55

14

41

  ≥ 48.360

29

14

15

28

5

23

ALB (g/L)

0.742

0.077

  < 4.296

43

20

23

42

13

29

  ≥ 4.296

46

23

23

41

6

35

GGT (U/L)

0.809

0.51

  < 77.101

61

30

31

56

14

42

  ≥ 77.101

28

13

15

27

5

22

CD4 expression

0.451

0.228

 Low

20

6

14

54

10

44

 High

70

37

33

30

9

21

CD8 expression

0.847

0.001

 Low

21

11

10

41

3

38

 High

69

32

37

43

16

27