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Fig. 4 | BMC Cancer

Fig. 4

From: Metagenomes of rectal swabs in larger, advanced stage cervical cancers have enhanced mucus degrading functionalities and distinct taxonomic structure

Fig. 4

Taxonomic profiling and biological models of MA metagenomes in LT- and ST-groups. a Taxonomic structure of metagenomes at the Phyla level. b Density plots of differentially abundant species in LT- and ST-groups. Fisher’s test and Mann Whitney tests were used to find differentially abundant OTUs with p-value < 0.05 (either test) without adjustment. c Richness, diversity, and evenness of OTUs in LT and ST-groups. d Taxonomic annotation of most abundant contigs in LT- and ST-groups. e Glycan degradation pathway in terms of enzyme abundances (top) and representative taxonomic Order (bottom) of the enzymes in each patient. The clinical characteristics of each patient and the Glycan degradation pathway activity score are given at the bottom of the table. To reveal taxa involved in the glycan degradation pathway in each metagenome we have selected contigs that encode enzymes involved in the pathway and quantify abundances of each taxa considering length and read coverage of the contigs. The figure overlays abundances of enzymes with the relative abundances of taxa involved in glycan degradation across metagenomes. Samples (X axis) in the figure have the same order as in the unsupervised clustering of samples in terms of KOs in Fig 1c. f Biological models of Mucus Adjoining (MA) bacterial consortium in LT- and ST-groups

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