Fig. 1

Association of molecular functions of MA metagenomes with KEGG pathways and clinical characteristics of CC patients. a Large number of unique functions is associated with larger tumor size and advance CC stage. b Linear relationship between the number of unique functions and the tumor size. c Unsupervised hierarchical clustering of metagenomes in terms of abundances of molecular functions. The heat map of the clustering shows abundances of 2396 KOs as rows and 41 MA metagenomes as columns. Boxes with enriched KEGG pathways are colored by red if the clustered molecular functions are more abundant in metagenomes of patients with Large tumors (Cluster 1) and in green if the molecular functions are more abundant in metagenomes of patients with Small tumors (Cluster 2). d Synthesis of peptidoglycan, lipopolysaccharides and biotin are enriched among KOs that are abundant in Cluster 2 (Small tumor) metagenomes. e Glycan degradation, ethanolamine utilization and production of ornithine are enriched among KOs that are abundant in Cluster 1 (Large tumor) metagenomes. Enzymes involved in the enriched pathways have red borders if they are found among KOs of the Cluster 1 or Cluster 2