Table 2 Prediction performance of the most important features for predicting the EGFR mutation, exon-19 deletion and exon-21 L858R

exponential_glszm_SmallArea

Emphasis (F1)

−0.20 ± 0.87

0.38 ± 1.13

–

–

0.652

0.010

exponential_ngtdm_Strength (F2)

−0.19 ± 0.55

0.36 ± 1.47

–

–

0.629

0.029

log-sigma-3-0-mm-3D_glcm_InverseVariance (F3)

0.17 ± 1.00

−0.32 ± 0.92

–

–

0.649

0.009

log-sigma-5-0-mm-3D_glrlm_Long

RunHighGrayLevelEmphasis (F4)

−0.15 ± 0.92

0.29 ± 1.1

–

–

0.640

0.019

wavelet-HHL_glcm_ ClusterShade (F5)

0.11 ± 1.09

−0.2 ± 0.77

–

–

0.632

0.017

wavelet-HHL_glrlm_GrayLevel NonUniformityNormalized (F6)

0.10 ± 1.15

−0.19 ± 0.59

–

–

0.633

0.032

wavelet-HHL_glrlm_Long RunHighGrayLevelEmphasis (F7)

−0.18 ± 0.64

0.34 ± 1.41

–

–

0.624

0.048

wavelet-LLL_glszm_Small AreaLowGrayLevelEmphasis (F8)

−0.03 ± 0.68

0.07 ± 1.44

–

–

0.658

0.011

original_shape_Elongation (F9)

–

–

0.42 ± 0.85

–

0.723

< 0.001

square_glrlm_LongRunHighGray

LevelEmphasis (F10)

–

–

0.45 ± 1.40

–

0.675

0.011

wavelet_LLL_firstorder_Skewness (F11)

–

–

0.38 ± 1.27

–

0.647

0.056

lbp-3D-k_glszm_ SmallAreaLowGrayLevelEmphasis (F12)

–

–

–

0.23 ± 0.89

0.628

0.067

log-sigma-3-0-mm-3D_glszm_ SmallAreaLowGrayLevelEmphasis (F13)

–

–

–

0.29 ± 1.34

0.673

0.008

log-sigma-5-0-mm-3D_glcm_Imc2 (F14)

–

–

–

0.33 ± 0.65

0.645

0.031

square_glszm_SizeZoneNonUniformityNormalized (F15)

–

–

–

0.29 ± 0.77

0.621

0.078

wavelet-LHL_firstorder_Median (F16)

–

–

–

0.39 ± 0.66

0.639

0.038