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Fig. 8 | BMC Cancer

Fig. 8

From: Construction of a novel model based on cell-in-cell-related genes and validation of KRT7 as a biomarker for predicting survival and immune microenvironment in pancreatic cancer

Fig. 8

Identification of the correlation between KRT7 high expression and immune-suppressive status based on integrated analysis of bulk-seq and scRNA-seq. A Volcano plot of the DEGs between the high and low KRT7 expression groups in TCGA cohort. Patients were stratified into the high and low groups according to the median of KRT7 expression. B Comparison of estimate score, immune score and stromal score between the high and low KRT7 expression groups in TCGA cohort. C Correlation analyses between the expression of KRT7 and immune-related genes, including eight immune checkpoints in TCGA cohort. D and E The UMAP plots of diverse cell types in PDAC tissues colored by major cell lineage (D) and eight malignant clusters colored by cluster (E). F Relative expression of KRT7 among eight malignant clusters visualized by UMAP projection. G Relative expression of KRT7 and immune-related genes in each malignant clusters visualized by dot plot. **, P < 0.01 and ***, P < 0.001

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BMC Cancer

ISSN: 1471-2407

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