Fig. 4

Different immune checkpoint profiles and immunotherapeutic responses of risk subgroups. A The association between RiskScore value and stromal score, immune score, ESTIMATE score, and tumor purity in the TCGA cohort. B The expression levels of 23 immune checkpoint profiles in LGG with different risk subgroups in the TCGA cohort. C Bar plot showing different responses to anti-PD-1 immunotherapy among 27 patients with melanoma between two risk subgroups. D Bar plot showing different responses to anti-PD-L1 immunotherapy among 298 patients with urothelial carcinoma between two risk subgroups. E Comparison of TIDE scores between Risk-H and Risk-L groups. *P < 0.05, **P < 0.01, and ***P < 0.001