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Table 1 Main characteristics of the 44 paediatric patients with MLL-r AML undergoing HSCT

From: Outcomes of allogeneic haematopoietic stem cell transplantation for paediatric patients with MLL-rearranged acute myeloid leukaemia

Items No. patients Percentage
Age(years)
  Median range 9.0(1.1–17.0)  
  < 10 24 54.5%
  ≥ 10 20 45.5%
Sex
  Female 19 43.2%
  Male 25 56.8%
FAB subtype
  M2 6 13.6%
  M4 7 15.9%
  M5 27 61.4%
  M6 2 4.5%
  M7 2 4.5%
MLL-r subtype
  t(9;11)(p22;q23)/AF9 10 22.7%
  MLL-PTD 8 18.2%
  t(10;11)(p13;q23)/AF10 7 15.9%
  t(11;19)(q23;p13.1)/ELL 5 11.4%
  t(6;11)(q27;q23)/AF6 4 9.1%
  t(1;11)(q21;q23)/AF1q 3 6.8%
  t(11;19)(q23;p13.3)/ENL 2 4.5%
  other MLL-r 5 11.4%
Additional gene abnormalities
  EVI1 7 15.6%
  FLT3-ITD 8 17.8%
Risk stratification
  High risk 35 79.5%
  Intermediate risk 9 20.5%
Cycles of induction to achieve CR
  1 27 61.4%
  2 12 27.3%
  3 5 11.4%
MRD- after 2 cycles of induction
  Yes 23 52.3%
  No 21 47.7%
CNS infiltration
  Yes 7 15.9%
  No 37 84.1%
Donor source
  HID 37 84.1%
  Non-HID 7 15.9%
  MUD 1  
  MSD 6  
Donor gender
  Male 36 81.8%
  Female 8 18.2%
  Donor age(Median range) 33.0(6.0–45.0)  
Relationship between donor and recipient
  Father 31 70.5%
  Mother 5 11.4%
  Brother 4 9.1%
  Sister 3 6.8%
  Unrelated 1 2.3%
Source of stem-cells
  BM and Pb 43 97.7%
  Pb 1 2.3%
  Median mononuclear cells × 108/kg(range) 9.42(3.1–16.1)  
  Median CD34 + counts × 106/kg(range) 2.61(0.76–10.7)  
  1. MLL-r MLL rearrangement, CNS central nervous system, HID haploidentical donors, MUD matched unrelated donor, MSD matched sibling donor, BM bone marrow, Pb peripheral blood, PTD partial tandem duplication, EVI1 ecotropic viral integration site 1, FLT3-ITD fms-like tyrosine kinase 3 internal tandem duplication