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Table 2 Factors that interfere with 25-hydroxyvitamin D concentration in the breast cancer survivors during endocrine therapy

From: Serum 25-hydroxyvitamin D and cancer-related fatigue: associations and effects on depression, anxiety, functional capacity and health-related quality of Life in breast cancer survivors during adjuvant endocrine therapy

Factors

Overall (n = 89)

25(OH)D

p

 < 75 nmol/L(n = 35)

 ≥ 75 nmol/L(n = 54)

Age (years)

64.0 (7.7)

64.6 (7.6)

63.6 (7.8)

0.470 *

 < 60

25 (28.1)

7 (28.0)

18 (72.0)

0.172θ

 ≥ 60

64 (71.9)

28 (43.8)

36 (56.3)

 

Educational Level

  Below high school

61 (68.5)

26 (42.6)

35 (57.4)

0.347θ

  High school or higher education

28 (31.5)

9 (32.1)

19 (67.9)

 

Race Group

  White

83 (93.3)

33 (39.8)

50 (60.2)

1.000℧

  Black

6 (6.7)

2 (33.3)

4 (66.7)

 

Income (minimum wage)

  < 3

53 (59.6)

23 (43.4)

30 (56.6)

0.340θ

  â‰¥â€‰3

36 (40.4)

12 (33.3)

24 (66.7)

 

Physical exercise

  No

53 (59.6)

22 (41.5)

31 (58.5)

0.262θ

  Yes

36 (40.4)

13 (36.1)

23 (63.9)

 

Current Smoking

  No

80 (89.9)

30 (37.5)

50 (62.5)

0.308θ

  Yes

9 (10.1)

5 (55.6)

4 (44.4)

 

Alcohol Intake

  No

66 (74.2)

29 (43.9)

37 (56.1)

0.131θ

  Yes

23 (25.8)

6 (26.1)

17 (73.9)

 

Supplementation

  No

75 (84.3)

29 (38.7)

46 (61.3)

0.193℧

  Yes, vitamin D

3 (3.4)

0 (0.0)

3 (100.0)

 

  Yes, calcium

2 (2.2)

2 (100.0)

0 (0.0)

 

  Yes, both

9 (10.1)

4 (44.4)

5 (55.6)

 

Season of the blood draw

  Summer

44 (49.4)

13 (29.5)

31 (70.5)

0.039θ

  Autumn

30 (33.7)

12 (40.0)

18 (60.0)

 

  Winter

15 (16.9)

10 (66.7) a

5 (33.3) b

 

Months since start on AI

29.5 (18.1–41.8)

25.5 (18.3 – 38.7)

30.0 (17.8 -48.1)

0.413 **

Daily Sun Exposure (minutes/day)

30 (15—60)

30 (10—60)

30 (18.8—60)

0.313 **

BMI (Kg/m2)

28.3 (25.4–31.4)

28.7 (25.4–31.4)

28.0 (25.3–31.6)

0.804 **

Body Fat (Kg)

28.3 (24–34.9)

27.7 (24.8–36.2)

28.5 (23.9–34.3)

0.781 **

Body Fat (%)

40.2 (36.8–44.4)

40.2 (36.7–47.6)

40.9 (37.6–44.3)

0.904 **

Calcium Concentration (mg/dL)

9.4 (9.2–9.9)

9.4 (9.1–9.8)

9.5 (9.3–9.9)

0.173 **

Parathyroid Hormone Concentration (pg/mL)

44.0 (33.2–55.3)

43.0 (32.6–57.5)

44.9 (34.2–54.3)

0.886 **

Milk product intake (g)

112.1 (27.5–222.0)

123.3 (28.5–225.3)

96.04 (12.9–221.6)

0.491 **

  No

10 (11.2)

2 (20.0)

8 (80.0)

0.304 ℧

  Yes

79 (88.8)

33 (41.8)

46 (58.2)

 

Fish and Seafood intake

  No

72 (80.9)

31 (43.1)

41 (56.9)

0.174θ

  Yes

17 (19.1)

4 (23.5)

13 (76.5)

 

Egg intake

  No

55 (61.8)

20 (36.4)

35 (63.6)

0.467θ

  Yes

34 (38.2)

15 (44.1)

19 (55.9)

 

Dietary Intake

Vitamin D (µg)

3.5 (2.3–5.0)

3.5 (2.4–5.0)

3.5 (2.2–5.0)

0.967 **

Calcium (mg)

475.8 (375.1–586.7)

464.9 (377.5–558.8)

478.2 (371.1–591.9)

0.788 **

Total Fat (g)

47.8 (5.0)

47.0 (4.3)

48.4 (5.4)

0.196 *

MUFA (g)

16.4 (2.4)

15.8 (2.2)

16.8 (2.4)

0.478 *

PUFA (g)

12.0 (1.7)

12.2 (1.5)

11.9 (1.8)

0.052 *

MUFA/PUFA Ratio

1.4 (1.2–1.6)

1.3 (1.1–1.4)

1.4 (1.3–1.6)

0.012 **

Omega-3 (g)

1.5 (1.4–1.6)

1.5 (1.4–1.6)

1.5 (1.4–1.6)

0.551 **

Omega-6 (g)

10.4 (1.5)

10.7 (1.2) a

10.2 (1.7) b

0.016 *

n6/n3 fatty acids ratio

7.0 (6.5 – 7.4)

7.1 (6.9 – 7.4)

6.7 (6.3 – 7.5)

0.193 **

Magnesium (mg)

192.6 (173.6–216.4)

195.8 (176.1–221.4)

192.6 (172.8–207.7)

0.518 **

Zinc (mg)

8.7 (1.4)

8.8 (1.5)

8.6 (1.4)

0.534 *

Fiber (g)

15.7 (3.8)

16.5 (4.1)

15.1 (3.5)

0.113 *

  1. Continuous variables are shown as mean (standard deviation) or median (p25-p75), and categorical variables are shown as absolute numbers and percentage frequency (in parentheses); Time point: T0, Baseline; 25(OH)D, 25-hydroxyvitamin D; AI, aromatase inhibitor; BMI Body Mass Index, MUFA Total Monounsaturated Fatty Acids, PUFA Total Polyunsaturated Fatty Acids, n6/n3 fatty acids ratio, estimated ratio of omega-6 to omega-3 fatty acids. The Brazilian minimum wage was R$ 880.00
  2. θChi-Square Independence Test
  3. ℧Fisher Exact Test
  4. * Test-t Independent
  5. ** Mann–Whitney. Different superscript letters represent statistical significance when comparing column proportions. Bold value is statistically significant at p < 0.05