Table 2 Univariate and multivariate analyses of overall survival in patients with LUAD in TCGA

Pathologic stage (Stage III&IV vs. Stage I&II)

518

2.664 (1.960–3.621)

 < 0.001

2.318 (1.602–3.355)

 < 0.001

Gender (Male vs. Female)

526

1.070 (0.803–1.426)

0.642

Race (White vs. Asian&Black or African American)

468

1.475 (0.902–2.411)

0.121

Age (> 65 vs. ≤ 65)

516

1.223 (0.916–1.635)

0.172

Smoker (Yes vs. No)

512

0.894 (0.592–1.348)

0.591

Number pack years smoked (≥ 40 vs. < 40)

363

1.004 (0.997–1.011)

0.223

Anatomic neoplasm subdivision

(Right vs. Left)

512

1.037 (0.770–1.397)

0.810

Anatomic neoplasm subdivision (Peripheral Lung vs. Central Lung)

182

0.913 (0.570–1.463)

0.706

Residual tumor (R1&R2 vs. R0)

363

3.879 (2.169–6.936)

 < 0.001

2.475 (1.341–4.570)

0.004

EFNA1 (High vs. Low)

526

1.017 (0.764–1.355)

0.906

EFNA2 (High vs. Low)

526

1.691 (1.262–2.266)

 < 0.001

1.247 (0.881–1.766)

0.213

EFNA3 (High vs. Low)

526

1.429 (1.071–1.908)

0.015

1.279 (0.911–1.795)

0.155

EFNA4 (High vs. Low)

526

0.990 (0.744–1.318)

0.947

EFNA5 (High vs. Low)

526

1.601 (1.198–2.141)

0.001

1.731 (1.238–2.420)

0.001