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Table 2 Univariate and Multivariate analysis of PFS and OS for NPC patients with negative EBV DNA in training cohort (n = 170)

From: Prognostic value of systemic inflammation response index in nasopharyngeal carcinoma with negative Epstein-Barr virus DNA

Variables

Univariate analysis

Multivariate analysis

HR (95%CI)

p

HR (95%CI)

p

PFS

Gender (female vs. male)

0.816 (0.401–1.658)

0.574

-

-

 Age (> 55 vs. ≤ 55)

1.619 (0.780–3.362)

0.196

-

-

 Smoke (yes vs. no)

1.121 (0.568–2.214)

0.741

-

-

 AJCC stage (8th) (III-IVb vs. I-II)

1.602 (0.730–3.516)

0.240

-

-

 Tumor classification (T3-4 vs. T1-2)

1.873 (0.921–3.809)

0.083

-

-

 Node classification (N2-3 vs. N0-1)

1.021 (0.530–1.965)

0.951

-

-

 Metastasis (Yes vs. No)

1.894 (0.454–7.893)

0.381

-

-

 WHO pathologic type (TypeIIb vs. TypeIIa vs. TypeI)

1.154 (0.354–3.762)

0.813

-

-

 Leukocytes (> 9.5 vs. ≤ 9.5)

1.835 (0.649–5.189)

0.253

-

-

 Neutrophils (> 6.3 vs. ≤ 6.3)

2.133 (0.829–5.489)

0.116

-

-

 Lymphocytes (> 3.2 vs. ≤ 3.2)

1.952 (0.468–8.145)

0.359

-

-

 Monocytes (> 0.6 vs. ≤ 0.6)

1.355 (0.526–3.491)

0.529

-

-

 Platelets (> 300 vs. ≤ 300)

3.248 (1.622–6.504)

0.001

1.976 (0.897–4.354)

0.091

 SII (> 655.54 vs. ≤ 655.54)

3.876 (2.005–7.493)

 < 0.001

1.467 (0.558–3.861)

0.437

 SIRI (> 1.12 vs. ≤ 1.12)

4.471 (2.303–8.678)

 < 0.001

3.032 (1.251–7.348)

0.014

OS

 Gender (female vs. male)

0.727 (0.259–2.038)

0.544

-

-

 Age (> 55 vs. ≤ 55)

2.734 (1.058–7.065)

0.038

2.412 (0.928–6.271)

0.071

 Smoke (yes vs. no)

2.010 (0.798–5.064)

0.139

-

-

 AJCC stage (8th) (III-IVb vs. I-II)

3.763 (0.865–16.371)

0.077

-

-

 Tumor classification (T3-4 vs. T1-2)

2.972 (0.978–9.035)

0.055

-

-

 Node classification (N2-3 vs. N0-1)

1.135 (0.450–2.859)

0.789

-

-

 Metastasis (Yes vs. No)

3.916 (0.899–17.064)

0.069

-

-

 WHO pathologic type (TypeIIb vs. TypeIIa vs. TypeI)

1.814 (0.241–13.636)

0.563

-

-

 Leukocytes (> 9.5 vs. ≤ 9.5)

Not estimable

-

Not estimable

-

 Neutrophils (> 6.3 vs. ≤ 6.3)

Not estimable

-

Not estimable

-

 Lymphocytes (> 3.2 vs. ≤ 3.2)

Not estimable

-

Not estimable

-

 Monocytes (> 0.6 vs. ≤ 0.6)

0.525 (0.070–3.949)

0.531

-

-

 Platelets (> 300 vs. ≤ 300)

2.282 (0.813–6.410)

0.117

-

-

 SII (> 655.54 vs. ≤ 655.54)

3.563 (1.404–9.039)

0.007

1.416 (0.434–4.626)

0.564

 SIRI (> 1.12 vs. ≤ 1.12)

5.527 (2.129–14.348)

 < 0.001

4.141 (1.230–13.935)

0.022

  1. EBV DNA Epstein-Barr virus DNA, AJCC American Joint Committee on Cancer, WHO World Health Organization, SII Systemic immune-inflammation index, SIRI Systemic inflammation response index
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