Table 1 Characteristics of the samples in the included studies

Liu; Xin; Ma [11]

2015

China

50

N/I

No

N/A

N/A

N/A

T: 86

CIN I: 19

CIN II: 25

CIN III: 42

N/I

N/I

N/I

Zhang et al [8]

2015

China

193

N/I

N/I

N/I

N/I

N/I

186

N/I

N/I

N/I

Nagamitsu et al [12]

2016

Japan

31

39

N/I

N/I

N/I

N/I

T: 55

CIN I: 15

CIN II: 16

CIN III: 24

CIN I: 34

CIN II: 35

CIN III: 34

N/I

N/I

Sun et al [13]

2016

China

32

N/I

N/I

N/I

N/I

N/I

13

N/I

N/I

N/I

Kong et al [14]

2017

China

40

39

Yes

Liquid-Based Cytology

N/I

N/I

T: 68

CIN I: 21

CIN II: 23

CIN III: 24

39

Yes

Liquid-Based Cytology

Wei; Wen-Ming; Jun-Bo [15]

2017

China

120

N/I

N/I

N/I

N/I

N/I

120

N/I

N/I

N/I

Wang et al [16]

2018

China

50

N/I

N/I

N/I

N/I

N/I

HSIL: 50

LSIL: 50

N/I

N/I

N/I

Farzanehpour et al [17]

2019

Iran

36

36

Yes

PCR

Yes

16

66

68

18

47

Yes

PCR

Wang et al [18]

2019

China

42

40.94

Yes

N/I

No

N/A

T: 144

CIN I: 19

CIN II: 54

CIN III: 71

CIN I: 41.93

CIN II: 42.37

CIN III: 40.77

N/I

N/I

Yang; Zhang [19]

2019

China

50

43

Yes

N/I

No

N/A

T: 50

CIN I: 15

CIN II: 15

CIN III: 20

CIN I: 38.0

CIN II: 35.3

CIN III: 36.2

Yes

N/I

Zheng et al [20]

2019

China

50

50

N/I

N/I

N/I

N/I

T: 90

CIN I: 34

CIN II-III: 56

50

N/I

N/I

Zheng et al [21]

2020

China

41

42.71

N/I

N/I

N/I

N/I

40

43.88

N/I

N/I

Qiu et al [22]

2020

China

90

> = 50: 41

< 50: 49

N/I

N/I

N/I

N/I

45

> = 50: 20

< 50: 25

N/I

N/I

Aftab et al [23]

2021

Índia

50

N/I

Yes

PCR

Yes

16: 2

LSIL: 17

HSIL: 33

N/I

Yes

PCR

Hoelzle et al [24]

2021

Brasil

12

27,5

Yes

PCR

No

N/A

LSIL: 14

HSIL: 11

LSIL: 32

HSIL: 39

Yes

PCR

Ocadiz-Delgado et al [25]

2021

México

23

38

Yes

PCR

No

N/A

17

34

Yes

PCR

Yamanaka et al [26]

2021

Japão

34

42

N/I

N/I

N/I

N/I

64

CIN I: 34

CIN II: 35

CIN III: 34

N/I

N/I

Liu; Xin; Ma [11]

N/I

N/I

105

<= 50: 64

>  50: 41

FIGO

I-II: 74

III-IV: 31

Yes: 37

No: 68

Yes

N/I

Yes: 92

No: 13

N/I

Serum

Zhang et al [8]

N/I

N/I

184

N/I

N/I

N/I

N/I

N/I

N/I

N/I

Serum

Nagamitsu et al [12]

N/I

N/I

45

49

Ia: 7

Ib: 16

IIa: 7

IIb: 10

III: 3

IV: 2

N/I

N/I

N/I

N/I

N/I

Serum

Sun et al [13]

N/I

N/I

40

<= 60: 22

>  60: 18

Stage I: 12

Stage II,

III and IV:

28

Yes: 29

No: 11

Yes

N/I

Yes: 28

No: 12

N/I

Serum

Kong et al [14]

Yes (all)

N/I

18

39

FIGO

Ia - IIa

N/I

Yes

Liquid-

Based

Cytology

Yes (all)

N/I

Serum

Wei; Wen-Ming; Jun-Bo [15]

N/I

N/I

120

<  50: 59

> = 50: 61

FIGO

I-II: 77

III: 43

Yes: 47

No: 73

Yes

N/I

Yes: 81

No: 39

N/I

Plasma

Wang et al [16]

N/I

N/I

50

N/I

N/I

N/I

N/I

N/I

N/I

N/I

Serum

Farzanehpour et al [17]

Yes

16

53

18

61

N/I

N/I

Yes

PCR

Yes

16

Serum

Wang et al [18]

N/I

N/I

15

49.73

N/I

N/I

N/I

N/I

N/I

N/I

Plasma

Yang; Zhang [19]

No

N/A

50

48

Stage I: 15

Stage II: 15

Stages

III – IV: 20

N/I

Yes

N/I

No

N/A

Total Blood

Zheng et al [20]

N/I

N/I

63

50

N/I

N/I

N/I

N/I

N/I

N/I

Exosomes

Zheng et al [21]

N/I

N/I

40

50.39

FIGO

I B1– I B2:

26

II A1– II B2:

12

N/I: 2

Yes: 9

No: 25

N/I: 6

N/I

N/I

N/I

N/I

Serum

Qiu et al [22]

N/I

N/I

112

> = 50: 53

< 50: 59

I: 90

IIA:22

Yes: 20

No: 92

N/I

N/I

N/I

N/I

Serum

Aftab et al [23]

Yes

16

LSIL: 4

HSIL: 24

50

N/I

I: 10

II: 17

III: 18

IV: 5

N/I

Yes

PCR

Yes

HG

16: 37

CS

16: 40

18: 2

Urine

Hoelzle et al [24]

Yes

LSIL

33: 2

Outros: 3

HSIL

16: 3

31: 1

Outros: 3

13

47

N/I

N/I

Yes

PCR

Yes

16: 4

18: 2

33: 2

Outros: 4

Plasma

Ocadiz-Delgado et al [25]

Yes

16

23

50

N/I

N/I

Yes

PCR

Yes

16

Serum

Yamanaka et al [26]

N/I

N/I

46

49

FIGO

IA: 4

IB: 21

IIA: 4

IIB: 10

III: 3

IV: 4

Yes: 19

No: 16

N/I: 11

N/I

N/I

N/I

N/I

Serum