Table 1 Patient demographics and characteristics according to the EASIX score
Factor | Total (n = 265) | Low EASIX (n = 172) | High EASIX (n = 93) | P |
|---|---|---|---|---|
Sex | 0.428 | |||
Male | 148 (55.8) | 93 (54.1) | 55 (59.1) | |
Female | 117 (44.2) | 79 (45.9) | 38 (40.9) | |
Age, years | < 0.001 | |||
≤ 60 | 102 (38.5) | 83 (48.3) | 24 (25.8) | |
> 60 | 163 (61.5) | 89 (51.7) | 69 (74.2) | |
ECOG PS | < 0.001 | |||
0–1 | 189 (71.3) | 140 (81.4) | 49 (52.7) | |
2–3 | 76 (28.7) | 32 (18.6) | 44 (47.3) | |
Symptom stage | < 0.001 | |||
A | 218 (82.3) | 153 (89.0) | 65 (69.9) | |
B | 47 (17.7) | 19 (11.1) | 28 (30.1) | |
Ann Arbor Stage | < 0.001 | |||
I-II | 113 (42.6) | 90 (52.3) | 23 (24.7) | |
III-IV | 152 (57.4) | 82 (47.7) | 70 (75.3) | |
IPI | < 0.001 | |||
Low | 86 (32.5) | 78 (45.4) | 8 (8.6) | |
Low-intermediate | 55 (20.8) | 42 (24.4) | 13 (14.0) | |
High-intermediate | 56 (21.1) | 26 (15.1) | 30 (32.3) | |
High | 68 (25.6) | 26 (15.1) | 42 (45.2) | |
Revised IPI | < 0.001 | |||
Very good | 36 (13.6) | 35 (20.4) | 1 (1.1) | |
Good | 105 (39.6) | 85 (49.4) | 20 (21.5) | |
Poor | 124 (46.8) | 52 (30.2) | 72 (77.4) | |
NCCN-IPI | < 0.001 | |||
Low | 25 (9.4) | 22 (12.8) | 3 (3.2) | |
Low-intermediate | 94 (35.5) | 82 (47.7) | 12 (12.9) | |
High-intermediate | 89 (33.6) | 52 (30.2) | 37 (39.8) | |
High | 57 (21.5) | 16 (9.3) | 41 (44.1) | |
Bone marrow involvement | < 0.001 | |||
Yes | 231 (87.2) | 13 (7.6) | 21 (22.6) | |
No | 34 (12.8) | 159 (92.4) | 72 (77.4) | |
Number of extranodal sites of involvement | < 0.001 | |||
< 2 | 182 (68.7) | 132 (76.7) | 50 (53.8) | |
≥ 2 | 83 (31.3) | 40 (23.3) | 43 (46.2) | |
Tumor lysis syndrome | < 0.001 | |||
Yes | 12 (4.5) | 1 (0.6) | 11 (11.8) | |
No | 253 (95.5) | 171 (99.4) | 82 (88.2) | |
Renal involvement of lymphoma | 0.040 | |||
Yes | 14 (5.3) | 5 (2.9) | 9 (9.7) | |
No | 251 (94.7) | 167 (97.1) | 84 (90.3) | |
Chronic kidney disease | > 0.998 | |||
Yes | 9 (3.4) | 6 (3.5) | 3 (3.2) | |
No | 256 (96.6) | 166 (96.5) | 90 (96.8) | |
Bulky disease | 0.769 | |||
Yes | 214 (80.8) | 34 (19.8) | 17 (18.3) | |
No | 51 (19.2) | 138 (80.2) | 76 (81.7) | |
Lactate dehydrogenase | < 0.001 | |||
Elevated | 108 (40.8) | 72 (41.9) | 85 (91.4) | |
Normal | 157 (59.2) | 100 (58.1) | 8 (8.6) | |
Cell of origin | 0.113 | |||
GCB | 46 (17.4) | 26 (15.1) | 20 (21.5) | |
Non-GCB | 127 (47.9) | 79 (45.9) | 48 (51.6) | |
Not available | 92 (34.7) | 67 (39.0) | 25 (26.9) |