Skip to main content

Table 2 Associations of patient characteristics and cancer in persons with new-onset anaemia (by anaemia types)

From: Cancer risk in persons with new-onset anaemia: a population-based cohort study in Denmark

Patient characteristics

AI

HRa (95% CI)

CIIDA

HRa (95% CI)

IDA

HRa (95% CI)

Other

HRa (95% CI)

Unclassified

HRa (95% CI)

Events, n (%)b,c

Person years

446 (13.6%)

2118

103 (3.1%)

528

429 (13.1%)

7239

255 (7.8%)

4295

2052 (62.5%)

30,923

Age groups, years

 40–49

1

1

1

1

1

 50–59

1.58 (0.90–2.76)

2.50 (0.78–7.98)

3.34 (2.06–5.39)

3.37 (1.49–7.63)

3.10 (2.31–4.17)

 60–69

2.14 (1.27–3.62)

3.68 (1.35–10.06)

11.77 (7.64–18.14)

6.39 (2.92–13.98)

6.51 (4.95–8.56)

 70–79

2.46 (1.46–4.16)

9.50 (3.48–25.98)

18.32 (11.96–28.09)

6.95 (3.14–15.34)

7.24 (5.51–9.51)

 80–89

1.86 (1.08–3.23)

3.70 (1.25–10.94)

16.81 (10.74–26.30)

7.41 (3.31–16.59)

6.05 (4.59–8.00)

Anaemia severity d

 Mild

1

1

1

1

1

 Moderate

1.87 (1.49–2.35)

2.00 (1.31–3.06)

1.87 (1.49–2.34)

2.43 (1.75–3.37)

2.87 (2.54–3.25)

 Severe

3.66 (2.09–6.40)

1.22 (0.29–5.11)

4.05 (3.07–5.36)

2.72 (1.01–7.35)

6.47 (5.10–8.21)

Civil status

 Living alone

1

1

1

1

1

 Living with a partner

1.10 (0.89–1.35)

0.98 (0.66–1.46)

1.13 (0.92–1.39)

1.17 (0.88–1.55)

1.03 (0.94–1.13)

Educational level

 Low

1

1

1

1

1

 Medium

1.18 (0.96–1.46)

1.80 (1.15–2.81)

1.08 (0.86–1.35)

1.50 (1.12–2.01)

1.11 (1.00–1.23)

 High

1.04 (0.77–1.40)

1.36 (0.69–2.67)

1.40 (1.05–1.86)

1.23 (0.84–1.81)

1.08 (0.94–1.24)

Income

 Low

1

1

1

1

1

 Medium

1.08 (0.85–1.36)

0.62 (0.38–1.04)

0.82 (0.64–1.04)

0.95 (0.68–1.31)

0.89 (0.80–0.99)

 High

0.99 (0.76–1.29)

0.95 (0.53–1.30)

0.88 (0.67–1.16)

1.17 (0.84–1.64)

0.91 (0.80–1.03)

No. of comorbidities e

 0

1

1

1

1

1

 1

0.48 (0.37–0.63)

0.48 (0.28–0.81)

0.70 (0.55–0.89)

0.64 (0.46–0.88)

0.77 (0.69–0.86)

 2

0.62 (0.46–0.85)

0.58 (0.33–1.03)

0.52 (0.38–0.72)

0.71 (0.49–1.03)

0.60 (0.52–0.69)

  ≥ 3

0.44 (0.28–0.71)

0.25 (0.10–0.64)

0.59 (0.40–0.87)

0.48 (0.26–0.86)

0.54 (0.45–0.65)

Sex

 Men

1

1

1

1

1

 Women

0.68 (0.54–0.84)

0.69 (0.45–1.04)

0.44 (0.36–0.54)

0.61 (0.45–0.83)

0.60 (0.53–0.67)

  1. Abbreviations: AI Anaemia of inflammation, CI 95% confidence interval, CIIDA Combined inflammatory iron deficiency anaemia, HR Hazard ratio, IDA Iron deficiency anaemia, No Number, Unclassified The anaemia is not classifiable according to a guideline
  2. aAdjusted for age (continuous), anaemia severity, civil status, educational level, income, comorbidity, and sex
  3. bNon-melanoma skin cancer excluded
  4. cRow percentages
  5. dAnaemia severity was defined according to WHO’s guidelines: mild anaemia (haemoglobin > 110 g/L), moderate anaemia (haemoglobin 80–110 g/L) and severe anaemia (haemoglobin < 80 g/L)
  6. eComorbidity was registered ten years prior to the index date and categorized according to the chronic disease groups (CDGs)