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Table 2 Associations of patient characteristics and cancer in persons with new-onset anaemia (by anaemia types)

From: Cancer risk in persons with new-onset anaemia: a population-based cohort study in Denmark

Patient characteristics AI
HRa (95% CI)
CIIDA
HRa (95% CI)
IDA
HRa (95% CI)
Other
HRa (95% CI)
Unclassified
HRa (95% CI)
Events, n (%)b,c
Person years
446 (13.6%)
2118
103 (3.1%)
528
429 (13.1%)
7239
255 (7.8%)
4295
2052 (62.5%)
30,923
Age groups, years
 40–49 1 1 1 1 1
 50–59 1.58 (0.90–2.76) 2.50 (0.78–7.98) 3.34 (2.06–5.39) 3.37 (1.49–7.63) 3.10 (2.31–4.17)
 60–69 2.14 (1.27–3.62) 3.68 (1.35–10.06) 11.77 (7.64–18.14) 6.39 (2.92–13.98) 6.51 (4.95–8.56)
 70–79 2.46 (1.46–4.16) 9.50 (3.48–25.98) 18.32 (11.96–28.09) 6.95 (3.14–15.34) 7.24 (5.51–9.51)
 80–89 1.86 (1.08–3.23) 3.70 (1.25–10.94) 16.81 (10.74–26.30) 7.41 (3.31–16.59) 6.05 (4.59–8.00)
Anaemia severity d
 Mild 1 1 1 1 1
 Moderate 1.87 (1.49–2.35) 2.00 (1.31–3.06) 1.87 (1.49–2.34) 2.43 (1.75–3.37) 2.87 (2.54–3.25)
 Severe 3.66 (2.09–6.40) 1.22 (0.29–5.11) 4.05 (3.07–5.36) 2.72 (1.01–7.35) 6.47 (5.10–8.21)
Civil status
 Living alone 1 1 1 1 1
 Living with a partner 1.10 (0.89–1.35) 0.98 (0.66–1.46) 1.13 (0.92–1.39) 1.17 (0.88–1.55) 1.03 (0.94–1.13)
Educational level
 Low 1 1 1 1 1
 Medium 1.18 (0.96–1.46) 1.80 (1.15–2.81) 1.08 (0.86–1.35) 1.50 (1.12–2.01) 1.11 (1.00–1.23)
 High 1.04 (0.77–1.40) 1.36 (0.69–2.67) 1.40 (1.05–1.86) 1.23 (0.84–1.81) 1.08 (0.94–1.24)
Income
 Low 1 1 1 1 1
 Medium 1.08 (0.85–1.36) 0.62 (0.38–1.04) 0.82 (0.64–1.04) 0.95 (0.68–1.31) 0.89 (0.80–0.99)
 High 0.99 (0.76–1.29) 0.95 (0.53–1.30) 0.88 (0.67–1.16) 1.17 (0.84–1.64) 0.91 (0.80–1.03)
No. of comorbidities e
 0 1 1 1 1 1
 1 0.48 (0.37–0.63) 0.48 (0.28–0.81) 0.70 (0.55–0.89) 0.64 (0.46–0.88) 0.77 (0.69–0.86)
 2 0.62 (0.46–0.85) 0.58 (0.33–1.03) 0.52 (0.38–0.72) 0.71 (0.49–1.03) 0.60 (0.52–0.69)
  ≥ 3 0.44 (0.28–0.71) 0.25 (0.10–0.64) 0.59 (0.40–0.87) 0.48 (0.26–0.86) 0.54 (0.45–0.65)
Sex
 Men 1 1 1 1 1
 Women 0.68 (0.54–0.84) 0.69 (0.45–1.04) 0.44 (0.36–0.54) 0.61 (0.45–0.83) 0.60 (0.53–0.67)
  1. Abbreviations: AI Anaemia of inflammation, CI 95% confidence interval, CIIDA Combined inflammatory iron deficiency anaemia, HR Hazard ratio, IDA Iron deficiency anaemia, No Number, Unclassified The anaemia is not classifiable according to a guideline
  2. aAdjusted for age (continuous), anaemia severity, civil status, educational level, income, comorbidity, and sex
  3. bNon-melanoma skin cancer excluded
  4. cRow percentages
  5. dAnaemia severity was defined according to WHO’s guidelines: mild anaemia (haemoglobin > 110 g/L), moderate anaemia (haemoglobin 80–110 g/L) and severe anaemia (haemoglobin < 80 g/L)
  6. eComorbidity was registered ten years prior to the index date and categorized according to the chronic disease groups (CDGs)