Skip to main content

Table 4 Multivariable Cox regression analysis of subgroups of patients with NSCLC who received neoadjuvant therapy

From: Evaluation of log odds of positive lymph nodes in predicting the survival of patients with non-small cell lung cancer treated with neoadjuvant therapy and surgery: a SEER cohort-based study

Subgroups

LODDS<-1.07

-1.07 ≤ LODDS<-0.27

LODDS≥-0.27

HR

HR (95%CI)

P

HR (95%CI)

P

Age

  ≤ 60 years old

Reference

1.649 (1.319-2.061)

< 0.001

2.587 (1.924-3.477)

< 0.001

 61-67 years old

Reference

1.302 (0.985-1.721)

0.064

1.709 (1.148-2.544)

0.008

  ≥ 68 years old

Reference

1.299 (1.040-1.623)

0.021

2.018 (1.477-2.756)

< 0.001

Gender

 Female

Reference

1.197 (0.967-1.482)

0.098

1.893 (1.449-2.472)

< 0.001

 Male

Reference

1.503 (1.261-1.791)

< 0.001

2.252 (1.739-2.917)

< 0.001

Laterality

 Right

Reference

1.260 (1.060-1.498)

0.009

1.832 (1.456-2.305)

< 0.001

 Left

Reference

1.638 (1.320-2.033)

< 0.001

2.646 (1.936-3.617)

< 0.001

Primary site

 Main bronchus

Reference

1.207 (0.351-4.149)

0.766

5.019 (0.974-25.856)

0.054

 Upper lobe

Reference

1.415 (1.202-1.667)

< 0.001

2.305 (1.829-2.905)

< 0.001

 Middle lobe

Reference

1.853 (0.734-4.676)

0.192

1.741 (0.600-5.053)

0.308

 Lower lobe

Reference

1.375 (1.037-1.822)

0.027

1.813 (1.244-2.642)

0.002

 Overlapping lesion of lung

Reference

1.684 (0.562-5.046)

0.352

0.745 (0.126-4.396)

0.746

Differentiation

 Grade I

Reference

1.723 (0.680-4.362)

0.251

1.940 (0.538-6.998)

0.311

 Grade II

Reference

1.361 (1.030-1.800)

0.030

2.259 (1.592-3.205)

< 0.001

 Grade III

Reference

1.301 (1.077-1.571)

0.006

1.971 (1.521-2.554)

< 0.001

 Grade IV

Reference

0.764 (0.338-1.728)

0.518

0.245 (0.018-3.310)

0.290

 Unknown

Reference

2.298 (1.630-3.239)

< 0.001

2.923 (1.795-4.761)

< 0.001

T

 T1

Reference

1.302 (0.855-1.981)

0.219

1.821 (1.071-3.096)

0.027

 T2

Reference

1.582 (1.193-2.098)

0.001

2.003 (1.444-2.778)

< 0.001

 T3

Reference

1.468 (1.165-1.850)

0.001

2.115 (1.482-3.017)

< 0.001

 T4

Reference

1.184 (0.924-1.516)

0.182

2.291 (1.510-3.476)

< 0.001

N

 N0

Reference

0.987 (0.778-1.251)

0.911

NA

NA

 N1

Reference

1.393 (0.993-1.953)

0.055

1.939 (1.221-3.078)

0.005

 N2

Reference

1.786 (1.444-2.209)

< 0.001

2.523 (1.983-3.211)

< 0.001

 N3

Reference

5.538 (1.011-30.326)

0.049

3.885 (0.377-40.074)

0.254

Radiotherapy

 No/Unknown

Reference

1.532 (1.190-1.972)

0.001

2.901 (2.052-4.101)

< 0.001

 Yes

Reference

1.348 (1.149-1.582)

< 0.001

1.884 (1.513-2.346)

< 0.001

  1. HRs of multivariate analysis of subgroups were adjusted for age, sex, laterality, primary site, differentiation, T stage, N stage, and radiotherapy, except for the subgroup variable itself. LODDS, log odds of positive lymph nodes; NSCLC, non-small cell lung cancer; HR, hazard ratio; CI, confidence interval
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us