Fig. 1

Expression profiling of WNT ligands in distinctive tumors and matched normal tissues. A mRNA expression profiling of 19 WNTs in 26 kinds of tumors, matched adjacent normal tissues and human normal tissues (downloaded from Expression Atlas; https://www.ebi.ac.uk/gxa/experiments/E-MTAB-5200). All data used for analysis were normalized to TPM (Transcripts Per Million) and run in Pretty Heatmaps with R package version 3.6.3 (https://github.com/cran/pheatmap). We used the command “cluster_cols = false” to merely cluster genes, and Euclidean distance was used to calculate the distance. B Representative sub-clusters of WNT ligands that showed tissue or tumor-specific expression patterns. Two sets of normal skin data referred to the skin from normal leg and suprapubic skin separately. The normal brain data represented the whole brain tissue. SCC: cervical squamous cell carcinoma; RCC: renal cell carcinoma; CRCC: clear renal cell carcinoma; HCC: hepatocellular carcinoma; HNSC: squamous cell carcinoma of head and neck; LUSC: lung squamous cell carcinoma; BTCC: transitional cell carcinoma of bladder; GM: glioblastoma multiforme; BNL: B-cell non-Hodgkin lymphoma; CLL: chronic lymphocytic leukemia