Table 4 Criteria for S-1 pausing, resuming, and skipping, and reduction of docetaxel, oxaliplatin, and S-1 from the next course in the preoperative DOS chemotherapy
S-1 pausing | S-1 resuming | S-1 skipping | Docetaxel and S-1 reduction from the next course | Oxaliplatin reduction from the next course | |
|---|---|---|---|---|---|
Neutrophil count decreased | Grade 3 | Grade 1 | – | Grade 4 | |
Platelet count decreased | Grade 3 | Grade 0–1 | Grade 4 | Grade 3 | Grade 2 |
Creatinine increased | >1.5 mg/dL | ≦1.5 mg/dL | >2.0 mg/dL | >1.5 mg/dL | |
Febrile neutropenia | – | – | Grade 3 | Grade 3 | |
Infection | – | – | Grade 3 | Grade 3 | |
Diarrhea, Oral mucositis, Rash | Grade 2 | Grade 0–1 | Grade 3 | Grade 3 | |
Nausea, Fatigue | Grade 3 | Grade 0–1 | – | Grade 3 | |
Vomiting, Anorexia | Grade 3 | Grade 0–1 | – | Grade 3 | |
Infusion reaction | Grade 2 | Grade 0–1 | Grade 3 | – | |
Peripheral motor neuropathy | – | – | – | – | Grade 2,3 |
Peripheral sensory neuropathy | – | – | – | – | Grade 2,3 |
Hypernatremia, Hyponatremia, Hyperkalemia, Hypokalemia | Grade 3 | Grade 0–1 | Grade 4 | Grade 3 | |