Table 3 Prognostic factors for overall survival (OS): univariate and multivariate analyses
Factor | univariate | multivariate | ||||
|---|---|---|---|---|---|---|
HR | (95% CI) | P | HR | (95% CI) | P | |
Pretreatment T790M (ref = Low) | ||||||
 High | 1.87 | (0.99–3.55) | .055 | 2.16 | (1.11–4.20) | .024 |
Age (ref = < 70) | ||||||
  ≥ 70 | 2.13 | (1.09–4.17) | .028 | 1.79 | (0.87–3.69) | .12 |
Gender (ref = Female) | ||||||
 Male | 1.12 | (0.56–2.26) | .75 | 1.17 | (0.40–3.44) | .77 |
Smoking (ref = Never smoker) | ||||||
 Smoker | 1.34 | (0.68–2.66) | .40 | 1.25 | (0.43–3.61) | .69 |
EGFR Mt (ref = Exon21 L858R) | ||||||
 Exon19 deletion | 1.56 | (0.79–3.10) | .20 | 1.80 | (0.88–3.67) | .11 |
 Uncommon | 3.54 | (1.28–9.77) | .015 | 3.33 | (1.13–9.83) | .029 |
Pathological Stage (7th) (ref = IA) | ||||||
 IB-II | 3.51 | (1.55–7.95) | <.01 | 4.30 | (1.77–10.40) | .001 |
 III-IV | 9.68 | (4.14–22.67) | <.00001 | 12.10 | (4.83–30.29) | <.00001 |
Adjuvant Chemotherapy (ref = No) | ||||||
 Yes | 1.07 | (0.55–2.09) | .85 | 0.47 | (0.22–1.01) | .053 |