Table 2 Prognostic factors for recurrence-free survival (RFS): univariate and multivariate analyses
Factor | univariate | multivariate | ||||
|---|---|---|---|---|---|---|
HR | (95% CI) | P | HR | (95% CI) | P | |
Pretreatment T790M (ref = Low) | ||||||
 High | 1.51 | (1.01–2.25) | .045 | 1.56 | (1.03–2.36) | .035 |
Age (ref = < 70) | ||||||
  ≥ 70 | 1.85 | (1.23–2.79) | <.01 | 1.55 | (0.99–2.43) | .056 |
Gender (ref = Female) | ||||||
 Male | 1.16 | (0.75–1.81) | .50 | 1.93 | (1.06–3.52) | .032 |
Smoking (ref = Never smoker) | ||||||
 Smoker | 1.16 | (0.75–1.82) | .50 | 0.87 | (0.48–1.59) | .66 |
EGFR Mt (ref = Exon21 L858R) | ||||||
 Exon19 deletion | 1.03 | (0.68–1.55) | .90 | 1.02 | (0.66–1.57) | .93 |
 Uncommon | 1.03 | (0.41–2.58) | .95 | 0.53 | (0.20–1.40) | .20 |
Pathological Stage (7th) (ref = IA) | ||||||
 IB-II | 6.05 | (3.51–10.42) | <.00001 | 6.30 | (3.46–11.47) | <.00001 |
 III-IV | 19.43 | (10.80–34.96) | <.00001 | 25.46 | (13.11–49.44) | <.00001 |
Adjuvant Chemotherapy (ref = No) | ||||||
 Yes | 2.19 | (1.47–3.27) | <.001 | 0.87 | (0.55–1.38) | .56 |