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Table 2 Performances of biomarkers for the diagnosis of BCa

From: Soluble POSTN is a novel biomarker complementing CA153 and CEA for breast cancer diagnosis and metastasis prediction

 

AUC (95% CI)

Cut-off value

Sensitivity (%)

Specificity (%)

Healthy vs. All BCa

  POSTN

0.78 (0.72 – 0.83)a1

14.5

71.7

75.4

  CA153

0.68 (0.61 – 0.74)

16.7

45.7

89.9

  CEA

0.68 (0.61 – 0.74)

2.2

49.1

84.0

  POSTN + CA153

0.80 (0.75 – 0.85)c3

-

76.3

72.5

  POSTN + CEA

0.82 (0.77 – 0.87)c3

-

74.0

78.3

  POSTN + CA153 + CEA

0.83 (0.78 – 0.87)c3

-

70.5

81.1

Healthy vs. locoregional BCa

  POSTN

0.72 (0.65 – 0.79)b

14.2

65.2

73.9

  CA153

0.57 (0.49 – 0.64)

14.3

37.4

82.6

  CEA

0.62 (0.55 – 0.69)

2.1

46.1

79.7

  POSTN + CA153

0.74 (0.67 – 0.80)c1

-

68.7

71.0

  POSTN + CEA

0.77 (0.70 – 0.82)c3

-

86.1

59.4

  POSTN + CA153 + CEA

0.77 (0.70 – 0.83)c3

-

87.8

55.1

Locoregional BCa vs. distant BCa

  POSTN

0.78 (0.71 – 0.84)

25.8

67.2

79.1

  CA153

0.82 (0.76 – 0.88)

19.3

75.9

74.8

  CEA

0.68 (0.61 – 0.75)

2.6

63.8

70.4

  POSTN + CA153

0.84 (0.78 – 0.89) 3

-

84.5

71.3

  POSTN + CEA

0.81 (0.74 – 0.86)

-

58.6

92.1

  POSTN + CA153 + CEA

0.85 (0.78 – 0.90) 3

-

74.1

83.5

  1. a−c, in comparison with CA153: a, P < 0.05; b, P < 0.01; c, P < 0.001
  2. 1–3, in comparison with CEA: 1, P < 0.05; 2, P < 0.01; 3, P < 0.001