Table 3 Sensitivity correlation analysis between the independent prognostic genes and drugs based on the CellMiner Database

GSDMC

Ixazomib citrate

−0.57595479

1.47E-06

IL18

Pipamperone

−0.509024906

3.28E-05

IL18

Bortezomib

−0.508793631

3.31E-05

GSDMC

Midostaurin

−0.491860473

6.57E-05

GSDMC

Bortezomib

−0.463557491

0.000191399

IL18

Actinomycin D

−0.448998313

0.00032019

IL18

Estramustine

−0.440708258

0.000424876

IL18

Vemurafenib

−0.439369013

0.000444445

GSDMC

pralatrexate

−0.436058325

0.000496385

GSDMD

Fludarabine

0.431453794

0.000577795

IL18

Vinblastine

−0.402432989

0.001434584

IL18

Raloxifene

−0.396260817

0.001723

IL18

Arsenic trioxide

−0.394839745

0.001796347

IL18

Lomustine

−0.389369145

0.002105486

IL18

Carfilzomib

−0.387952286

0.00219293

IL18

Carmustine

−0.382263852

0.002577528

IL18

Depsipeptide

−0.380139576

0.002735875

GSDMC

Vismodegib

−0.379539246

0.002782165

GSDMD

Cladribine

0.379224295

0.002806728

GSDMC

Gefitinib

0.378968948

0.002826784

IL18

Ixazomib citrate

−0.377554717

0.002940186

IL18

Sulfatinib

−0.373232429

0.003312239

GSDMC

Vincristine

−0.368981618

0.003718274

IL18

Paclitaxel

−0.368430241

0.003774044

IL18

VINORELBINE

−0.360484258

0.00466406

GPX4

Selumetinib

−0.359505

0.004785642

IL18

Mithramycin

−0.359091919

0.004837761

IL18

Dabrafenib

−0.354169816

0.005498363

IL18

Homoharringtonine

−0.349851754

0.006141874

IL18

Vincristine

−0.341962731

0.007489547

GPX4

ARRY-162

−0.329858532

0.010058815

IL18

Vinorelbine

−0.328589792

0.010367904

IL18

Doxorubicin

−0.323741261

0.011626145

IL18

ETHINYL ESTRADIOL

−0.321734287

0.012184365

IL18

ARSENIC TRIOXIDE

−0.321556026

0.012235046

GPX4

Cobimetinib (isomer 1)

−0.319111208

0.012948702

GSDMD

Vinorelbine

−0.317517609

0.013432945

IL18

Irofulven

0.314947083

0.014246885

IL18

Epirubicin

−0.314263548

0.014470323

GPX4

Digoxin

0.312582561

0.015032651

GSDMD

Depsipeptide

−0.308463009

0.016490554

IL18

Teniposide

−0.308415202

0.016508159

IL18

Tamoxifen

−0.305102479

0.017767832

GPX4

Floxuridine

0.304346956

0.018066337

GSDMD

Ixazomib citrate

0.302574225

0.018783572

GSDMC

Dacomitinib

0.297738692

0.020864437

IL18

Tegafur

−0.296503111

0.021426482

IL18

Crizotinib

−0.296205911

0.021563573

GSDMD

Eribulin mesilate

−0.290597914

0.024293174

IL18

Afatinib

0.288715478

0.02527245

GSDMD

Nelarabine

0.283957854

0.027896746

IL18

Ixabepilone

−0.282683139

0.028637519

IL18

Encorafenib

−0.282663266

0.028649197

GSDMD

6-THIOGUANINE

0.281349635

0.029430039

IL18

Dacomitinib

0.281147048

0.029552033

IL18

Abiraterone

−0.278419627

0.031236075

GSDMD

Clofarabine

0.278163601

0.031398193

GSDMD

Floxuridine

0.278052059

0.031469043

GSDMD

Vismodegib

0.277730639

0.03167395

GSDMD

Gemcitabine

0.276118299

0.032718712

GPX4

LEE-011

−0.275011314

0.033452526

GPX4

Trametinib

−0.273321502

0.034599099

IL18

Erlotinib

0.273073537

0.034770066

IL18

Etoposide

−0.271955429

0.035549733

IL18

Nilotinib

−0.270877836

0.036314838

GPX4

Denileukin Diftitox Ontak

−0.27071664

0.036430455

GSDMD

Actinomycin D

−0.270591993

0.036520068

GPX4

Temsirolimus

0.270096569

0.036878052

GSDMC

Idarubicin

−0.26925671

0.037491565

GSDMD

Mithramycin

−0.268870062

0.03777684

GPX4

LDK-378

−0.268764945

0.037854707

IL18

Eribulin mesilate

−0.267440211

0.038847471

GSDMC

Carmustine

−0.266647795

0.039451539

GSDMC

DAUNORUBICIN

−0.265426515

0.040397727

GSDMC

Erlotinib

0.263596821

0.041850285

GPX4

Ibrutinib

0.26305371

0.042289643

GSDMD

Cytarabine

0.263023079

0.042314535

GSDMD

Vinblastine

−0.261927998

0.04321241

GSDMC

Bisacodyl, active ingredient of Viraplex

0.258236502

0.046355329

GSDMC

Pazopanib

−0.257997618

0.046565006

GSDMD

Neratinib

−0.25748124

0.047020905

GPX4

Vinorelbine

−0.257398217

0.047094544

GSDMD

Paclitaxel

−0.25630594

0.048072193