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Table 1 Cellular sensitivity to 3 key therapeutic drugs, docetaxel (TXT), cisplatin (CDDP), and 5-fluorouracil (5-FU)

From: Biomarker discovery for practice of precision medicine in hypopharyngeal cancer: a theranostic study on response prediction of the key therapeutic agents

Cell Line

Histology

Sensitivity to drug (IC50)

TXT

(pg/ml)

CDDP

(ÎĽg/ml)

5-FU

(ÎĽg/ml)

UTC-SCC-26A

hypopharyngeal squamous cell carcinoma

47.9094

8.3860

0.8209

UTC-SCC-26B

hypopharyngeal squamous cell carcinoma

0.1690

0.2828

0.0557

UTC-SCC-62

hypopharyngeal squamous cell carcinoma

6.2064

1.6152

1.1576

UTC-SCC-66

hypopharyngeal squamous cell carcinoma

207.9236

1.6044

0.1212

UTC-SCC-70

hypopharyngeal squamous cell carcinoma

9191.0864

2.3567

0.2077

UTC-SCC-89

hypopharyngeal squamous cell carcinoma

0.0940

0.5494

0.0435

UTC-SCC-94

hypopharyngeal squamous cell carcinoma

0.7811

1.3697

0.0766

BICR6

hypopharyngeal squamous cell carcinoma

0.1036

0.2122

0.4808

HPC-921Y

hypopharyngeal squamous cell carcinoma

9980.4473

2.8667

1.1515

MPC-881 T

mesopharyngeal squamous cell carcinoma

0.0422

0.3488

0.0548

MPC-882Y

mesopharyngeal squamous cell carcinoma

22,607.4900

0.3596

0.9589

UTC-SCC-4

oropharyngeal squamous cell carcinoma

8898.8459

0.9443

39.8870

UMB-ACC-745

oropharyngeal squamous cell carcinoma

0.0936

0.9743

0.3083

FaDu

pharyngeal squamous cell carcinoma

3798.9334

1.0897

2.2402

Detroit562

pharyngeal squamous cell carcinoma

3.3620

1.5133

2.1239

  1. IC50, inhibitory drug concentration of 50% cell growth: drug concentration of 50% optical density of control