Skip to main content
Fig. 4 | BMC Cancer

Fig. 4

From: Anesthetic propofol enhances cisplatin-sensitivity of non-small cell lung cancer cells through N6-methyladenosine-dependently regulating the miR-486-5p/RAP1-NF-κB axis

Fig. 4

MiR-486-5p deletion abolished the effect of propofol on DDP-resistant NSCLC cells. a-b The expression of miR-486-5p in DDP-resistant cells (a) and in xenografts tissue (b) were determined by QRT-PCR. Subsequently, the A549/DDP and SKMES/DDP cells were treated with or without miR-486-5p inhibitor, and intervened with high concentration of propofol (10 μg/mL). c The expression of miR-486-5p was detected to test transfection efficiency. d Cell viability was measured by CCK-8 assay. e Colony formation ability was evaluated by Giemsa staining. f The apoptosis was detected by flow cytometry. *P < 0.05. NC, negative control. Ppf, high concentration of propofol. miR in, miR-486-5p inhibitor

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us