Table 3 Data from 14 articles that externally validated 32 existing prognostic models for HCC patients undergoing systemic therapy
Model | c-statistics | 95%CI lower | 95%CI upper | Outcome | Type of cohort(N) | events(n) |
|---|---|---|---|---|---|---|
PROSASH-II | 0.65 | NA | NA | NA | Training (615) | 559 |
0.68 | 0.65 | 0.72 | OS | Validation (290) | 273 | |
0.63 | 0.6 | 0.65 | OS | Validation (552) | NA | |
PROSASH | 0.72 | 0.69 | 0.75 | OS | Training (500) | NA |
0.7 | 0.67 | 0.73 | OS | Validation (421) | ||
0.71 | 0.69 | 0.73 | OS | All(500 + 421) | ||
0.63 | 0.6 | 0.66 | OS | Validation (438) | NA | |
ALBI | 0.6 | NA | NA | NA | Validation (905) | NA |
0.595 | 0.566 | 0.625 | OS | Validation (468) | NA | |
0.56 | 0.51 | 0.6 | OS | Validation (681) | NA | |
0.59 | NA | NA | NA | Validation (615) | 559 | |
0.62 | 0.58 | 0.65 | NA | Validation (290) | 273 | |
0.53 | 0.51 | 0.56 | OS | Validation (552) | NA | |
0.638 | 0.599 | 0.676 | OS | Validation (900) | 598 | |
0.748 | 0.732 | 0.763 | OS | Validation (3182) | NA | |
Child–Pugh | 0.61 | NA | NA | NA | Validation (905) | NA |
0.53 | NA | NA | NA | Validation (615) | 559 | |
0.58 | 0.55 | 0.61 | OS | Validation (290) | 273 | |
0.584 | 0.539 | 0.629 | FFS | Validation (201) | 155 | |
0.592 | 0.547 | 0.637 | OS | Validation (201) | 155 | |
0.52 | 0.51 | 0.54 | OS | Validation (552) | NA | |
0.638 | 0.598 | 0.678 | OS | Validation (900) | 598 | |
BCLC | 0.637 | 0.58 | 0.695 | OS | Validation (435) | NA |
0.55 | 0.528 | 0.571 | OS | Validation (468) | NA | |
0.56 | 0.52 | 0.6 | OS | Validation (681) | NA | |
0.54 | NA | NA | NA | Validation (615) | 559 | |
0.57 | NA | NA | NA | Validation (290) | 273 | |
0.57 | 0.55 | 0.6 | OS | Validation (552) | NA | |
0.65 | NA | NA | OS | Validation (3628) | NA | |
0.64 | NA | NA | OS | Validation (1555) | NA | |
0.73 | NA | NA | OS | Validation (2651) | NA | |
0.739 | 0.709 | 0.769 | OS | Validation (1013) | NA | |
0.678 | 0.559 | 0.796 | OS | Validation (108) | NA | |
0.665 | 0.653 | 0.678 | OS | Validation (1969) | NA | |
0.71 | 0.67 | 0.74 | OS | Validation (904) | 508 | |
0.727 | 0.692 | 0.762 | OS | Validation (900) | 598 | |
0.807 | 0.773 | 0.824 | OS | Validation (1188) | 652 | |
HAP | 0.653 | 0.624 | 0.681 | OS | Validation (468) | NA |
0.6 | NA | NA | NA | Validation (615) | 559 | |
0.67 | 0.64 | 0.7 | OS | Validation (290) | 273 | |
0.59 | 0.56 | 0.62 | OS | Validation (552) | NA | |
SAP | 0.64 | 0.614 | 0.667 | OS | Validation (468) | NA |
0.6 | NA | NA | NA | Validation (615) | 559 | |
0.69 | 0.66 | 0.72 | OS | Validation (290) | 273 | |
0.58 | 0.55 | 0.61 | OS | Validation (552) | NA | |
JIS | 0.691 | 0.638 | 0.744 | OS | Validation (435) | NA |
0.55 | NA | NA | OS | Validation (615) | 559 | |
0.59 | 0.55 | 0.62 | OS | Validation (290) | 273 | |
0.67 | NA | NA | OS | Validation (3628) | NA | |
0.67 | NA | NA | OS | Validation (1555) | NA | |
0.7 | NA | NA | OS | Validation (2651) | NA | |
0.753 | 0.748 | 0.771 | OS | Validation (1969) | NA | |
0.7 | 0.66 | 0.73 | OS | Validation (477) | 295 | |
0.78 | 0.76 | 0.8 | OS | Validation (904) | 508 | |
0.798 | 0.774 | 0.823 | OS | Validation (1188) | 652 | |
CLIP | 0.542 | 0.485 | 0.599 | OS | Validation (435) | NA |
0.66 | 0.6 | 0.72 | OS | Validation (681) | NA | |
0.642 | 0.604 | 0.68 | FFS | Validation (201) | 155 | |
0.642 | 0.605 | 0.679 | OS | Validation (201) | 155 | |
0.69 | NA | NA | OS | Validation (3628) | NA | |
0.68 | NA | NA | OS | Validation (1555) | NA | |
0.75 | NA | NA | OS | Validation (2651) | NA | |
0.76 | 0.748 | 0.771 | OS | Validation (1969) | NA | |
0.7 | 0.66 | 0.74 | OS | Validation (477) | 295 | |
0.75 | 0.73 | 0.77 | OS | Validation (904) | 508 | |
0.777 | 0.744 | 0.809 | OS | Validation (900) | 598 | |
0.75 | 0.727 | 0.774 | OS | Validation (1188) | 652 | |
Okuda | 0.632 | 0.577 | 0.687 | OS | Validation (435) | NA |
0.64 | 0.6 | 0.69 | OS | Validation (681) | NA | |
0.639 | 0.601 | 0.676 | FFS | Validation (201) | 155 | |
0.68 | 0.641 | 0.718 | OS | Validation (201) | 155 | |
0.733 | 0.718 | 0.748 | OS | Validation (1973) | NA | |
JRC | 0.755 | 0.707 | 0.803 | OS | Training (435) | NA |
AJCC TNM7 | 0.56 | 0.5 | 0.62 | OS | Validation (681) | NA |
0.755 | 0.724 | 0.785 | OS | Validation (1013) | NA | |
0.741 | 0.635 | 0.847 | OS | Validation (108) | NA | |
0.675 | 0.659 | 0.691 | OS | Validation (1973) | NA | |
SCHCC | 0.818 | NA | NA | OS | Training (612) | NA |
MESIAH | 0.77 | 0.74 | 0.8 | OS | Training (477) | 295 |
0.82 | 0.8 | 0.83 | OS | Validation (904) | 508 | |
0.69 | NA | NA | OS | Validation (3628) | NA | |
0.69 | NA | NA | OS | Validation (1555) | NA | |
0.77 | NA | NA | OS | Validation (2651) | NA | |
0.835 | 0.81 | 0.861 | OS | Validation (1013) | NA | |
0.785 | 0.687 | 0.884 | OS | Validation (108) | NA | |
0.792 | 0.782 | 0.803 | OS | Validation (1969) | NA | |
Modified BCLC | 0.66 | NA | NA | OS | Validation (3628) | NA |
0.66 | NA | NA | OS | Validation (1555) | NA | |
0.75 | NA | NA | OS | Validation (2651) | NA | |
HKLC | 0.68 | NA | NA | OS | Validation (3628) | NA |
0.68 | NA | NA | OS | Validation (1555) | NA | |
0.75 | NA | NA | OS | Validation (2651) | NA | |
ITA.LA.CA | 0.57 | 0.54 | 0.59 | OS | Validation (552) | NA |
0.72 | NA | NA | OS | Training (3628) | NA | |
0.71 | NA | NA | OS | Validation (1555) | NA | |
0.78 | NA | NA | OS | Validation (2651) | NA | |
Tokyo score | 0.716 | 0.703 | 0.729 | OS | Validation (1969) | NA |
0.702 | 0.685 | 0.719 | OS | Validation (1973) | NA | |
0.767 | 0.742 | 0.793 | OS | Validation (1188) | 652 | |
APRI | 0.569 | 0.53 | 0.608 | OS | Validation (900) | 598 |
PALBI | 0.67 | 0.632 | 0.707 | OS | Validation (900) | 598 |
0.78 | 0.765 | 0.794 | OS | Validation (3182) | NA | |
FIB-4 score | 0.540 | 0.5 | 0.579 | OS | Validation (900) | 598 |
MELD | 0.591 | 0.551 | 0.631 | OS | Validation (900) | 598 |
0.664 | 0.647 | 0.68 | OS | Validation (3182) | NA | |
CTP | 0.742 | 0.727 | 0.757 | OS | Validation (3182) | NA |
CP-based BCLC | 0.757 | 0.741 | 0.774 | OS | Validation (1973) | NA |
ALBI-based BCLC | 0.76 | 0.743 | 0.776 | OS | Validation (1973) | NA |
CP-CLIP | 0.785 | 0.769 | 0.802 | OS | Validation (1973) | NA |
ALBI-CLIP | 0.789 | 0.772 | 0.806 | OS | Validation (1973) | NA |
ALBI-based JIS (ALBI-T) | 0.74 | 0.723 | 0.757 | OS | Validation (1973) | NA |
LCSGJ TNM | 0.686 | 0.67 | 0.703 | OS | Validation (1973) | NA |
CUPI | 0.708 | 0.696 | 0.72 | OS | Validation (1973) | NA |
0.701 | 0.679 | 0.722 | OS | Validation (1188) | 652 | |
CP-based JIS | 0.734 | 0.717 | 0.751 | OS | Validation (1973) | NA |
GRETCH | 0.688 | 0.664 | 0.713 | OS | Validation (1188) | 652 |