Fig. 6

Mido-ATRA results in significant tumor regression in mouse xenograft models of AML. (A) Mean tumor volumes in mice injected with HL-60, HL-60Res and U937 cells and treated as indicated. *P < 0.05 versus vehicle-treated mice. # P < 0.05 versus mido-treated mice. & P < 0.05 versus ATRA-treated mice. (B) Weights of HL-60, HL-60Res and U937 cell xenografts harvested on Day 21. *P < 0.05, **P < 0.01 versus vehicle-treated mice. & P < 0.05, && P < 0.01 versus ATRA-treated mice. #P < 0.05, ##P < 0.01 versus mido-treated mice. (C) Images of HL-60, HL-60Res and U937 cell xenografts harvested on Day 21