Fig. 6

PLAG treatment alters the secretion of cytokines and chemokines in mice with MB49 tumors. a,b G-CSF, a cytokine that contributes to tumor growth, and MIP-2, a neutrophil migration factor, were evaluated in tumor-bearing mice treated with PLAG. c,d Th1, IFN-gamma, and IL-12 cytokines from tumor-bearing mice treated with PLAG were analyzed by ELISA. e,f T cell growth factor, IL-2, Th2, and IL-4 cytokines from tumor-bearing mice treated with PLAG were analyzed by ELISA. Compared with the negative control: *P < 0.05, **P < 0.01***P < 0.001; compared with the tumor only: #P < 0.05, ##P < 0.01, ###P < 0.001; compared with the aPD-L1-only treatment group: $P < 0.05, $$P < 0.01, $$$P < 0.001 (n = 6 for each experiment). N.S, not significant. Mean ± SD