Fig. 3

Mutational profile of gene variants in 1p-intact neuroblastoma. A Waterfall plot of the distribution of mutations found in 56 neuroblastoma tumors, reflecting mutation type predicted according to Sift in each identified variant (main plot), frequency of mutations per sample (upper panel), frequency of samples mutated (left panel) and clinical-pathological variables (lower panel heatmap). UH: unfavorable histology, FH: favorable histology. B Correlation matrix of 15 genes with identified variants in 100 sequenced tumor-normal pairs; names of chromosome 1p genes in bold