Randomized trial of surveillance with abbreviated MRI in women with a personal history of breast cancer– impact on patient anxiety and cancer detection

Table 3 Outcomes according to surveillance group

	MG group n = 94	MG + A-MRI group n = 104, breast findings only	MG + A-MRI group n = 104, including extramammary findings
Outcome	MG group n = 94	MG + A-MRI group n = 104, breast findings only		P value**
False negative^a	3	0	0	-
True negative	87	77	74	-
False positive^b	3	22	24	-
True positive	1	5	6	-
Recall rate	4.3% (4/94)	26% (27/104)	28.9% (30/104)	< 0.0001
Biopsy rate	2.1% (2/94)	19.2% (20/104)	21.2% (22/104)	0.0001
CDR per 1000	10.6	48.1	58	0.1249
Cancers diagnosed per 1000 including follow-up	42.6	48.1	58	0.8522
PPV2 (biopsies recommended)	50% (1/2)	25% (5/20)	27.3% (6/22)	0.4805
PPV3 (biopsies performed)	50% (1/2)	25% (5/20)	27.3% (6/22)	0.4805
Sensitivity	25% (1/4)	100% (5/5)	100% (6/6)	0.048
Specificity	96.7% (87/90)	77.8% (77/99)	75.5% (74/98)	0.0001

^aFalse negatives includes breast cancers found at follow-up
^bIn the MG plus A-MRI surveillance group, 1 false positive was found with mammography and 2 false positives were found with both MG and A-MRI. All other false positives were found with A-MRI only
^**p values were obtained comparing the MG group with the MG + A-MRI surveillance groups for intramammary findings only

ISSN: 1471-2407