Fig. 6

Anti-CD38 antibody suppresses bladder tumor growth in vivo. A In vivo imaging of luciferase-expressing MB49 tumor-bearing mice after intravenous injection of IgG2a isotype control antibody or anti-CD38 monoclonal antibody. B The weight of tumors from IgG2a isotype control antibody or anti-CD38 monoclonal antibody -treated mice was analysed. Each symbol indicates one mouse (n = 5). C The H&E images of tumors from IgG2a isotype control antibody or anti-CD38 monoclonal antibody-treated mice. D-E Flow cytometric analysis and quantification of tumour-infiltrating CD38⁺ TAMs (n = 5). F-G Flow cytometric analysis and quantification of CD8⁺ T cells. H Correlation analysis between the percentage of CD38⁺ TAMs and the percentage of CD8⁺ T cells. R values by linear regression. I Kaplan–Meier survival analysis for the overall survival of IgG2a isotype control antibody or anti-CD38 monoclonal antibody-treated mice