Fig. 2

Top genes of the glucocorticoid pathway expressed in tumor tissue associated with mutation and prognosis. a. Association between glucocorticoid pathway tumor mutation burden (TMB) and individual gene expression by linear regression; b. Association between individual gene expression and breast cancer invasive disease-free survival (iDFS) by logistic regression TMB was classified as mutated or not. Gene expression was used as a continuous variable in log2 scale. Both regression models were adjusted for cohort membership, age at diagnosis, menopausal status at diagnosis, molecular subtype, and cancer stage. The genes with p values < 0.05 for both analyses were presented in this table