Clinical relevance of tertiary lymphoid structures in esophageal squamous cell carcinoma

BMC Cancer

Table 1 Correlations with the clinicopathological factors and density of the CD20⁺ B cells / number of CD8⁺ T cells

Characteristics		N	CD20			CD8
Characteristics		N	High	Low	p-Value	High	Low	p-Value
Age	< 70	152	108	44		112	40
Age	≥ 70	84	69	15	0.055	66	18	0.400
Sex	Male	194	142	52		141	53
Sex	Female	42	35	7	0.154	37	5	0.047^*a
History of other cancer	No	204	153	51		155	49
History of other cancer	Yes	32	24	8	1.000	23	9	0.660
Location	Ce / Ut	21	14	7		13	8
	Mt	142	111	31		107	35
	Lt / Ae	73	52	21	0.359	58	15	0.280
cT category	T 1 / 2	111	85	26		75	36
cT category	T 3 / 4	125	92	33	0.598	103	22	0.008^**
cN category	N -	88	64	24		57	31
cN category	N +	148	113	35	0.536	121	27	0.004^**
cStage category	0 - II	119	89	30		81	38
cStage category	III / IVa	117	88	29	0.940	97	20	0.008^**
Neoadjuvant Chemotherapy	No	84	62	22		57	27
Neoadjuvant Chemotherapy	Yes	152	115	37	0.754	121	31	0.047^*
Myelosuppression grade	≤ 2	131	98	33		105	26
	3	14	10	4		10	4
	4	7	7	0	0.130	6	1	0.695
pT category	T 1a / 1b / 2	137	103	34		95	42
pT category	T 3 / 4a	99	74	25	0.939	83	16	0.009^**
pN category	N 0	103	77	26		76	27
pN category	N 1 - 4	133	100	33	0.940	102	31	0.608
pStage category	0 - II	143	107	36		104	39
pStage category	III / IVa	93	70	23	0.939	74	36	0.229
Histological therapeutic effect	0 / 1a	114	86	28		90	24
Histological therapeutic effect	1b / 2	38	29	9	0.913	33	7	0.725
Adjuvant chemotherapy	No	135	106	29		103	32
Adjuvant chemotherapy	Yes	101	71	30	0.150	75	26	0.719

Ce Cervical esophagus, Ut Upper thoracic esophagus, Mt Middle thoracic esophagus, Lt lower thoracic esophagus, Ae Abdominal esophagus, T Depth of invasion, N Nodal status
^*p < 0.05,
^**p < 0.01, statistically significant
^aFisher’s exact test

ISSN: 1471-2407