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Fig. 1 | BMC Cancer

Fig. 1

From: Targeting autophagy increases the efficacy of proteasome inhibitor treatment in multiple myeloma by induction of apoptosis and activation of JNK

Fig. 1

IRE1α inhibitors in combination with ixazomib have synergistic effects on cytotoxicity of multiple myeloma cells under support of mesenchymal stromal cell line (hMSC-TERT). A KMS11 and RPMI-8226 cells were treated with 10 nM ixazomib alone or combined with 30 μM STF-083010 for five days with or without support of immortalized stromal cells (hMSC-TERT), (n = 3). Cell viability were measured by PI staining. B Total RNA was extracted after 16 h of treatment as described above. B, C XBP1s, ATF6 and EIF2AK3 mRNA levels were assessed using RT-qPCR, (n = 3). P values were calculated by two-way analysis of variance (ANOVA) for A, B and one-way analysis for C. A P value of less than 0.05 was considered statistically significant for all analyses. (*p < 0.05, **p < 0.01, ***p < 0.001 versus control)

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BMC Cancer

ISSN: 1471-2407

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